Geriatric nutritional risk index predicts cancer prognosis in patients with local advanced rectal cancer undergoing chemoradiotherapy followed by curative surgery

Table 3 Univariate and multivariate analyses of predictive factors associated with overall survival in patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiotherapy

		Univariate analysis			Multivariate analysis
Variable		HR	95% CI	p value	HR	95% CI	p value
Sex	Male vs. female	2.67	0.92–11.26	0.072
Age (years)	> 63 vs. ≤63	1.06	0.49–2.31	0.88
Histological type	Poor/mucinous vs. well/moderate	1.36	0.40–3.57	0.58
Pathological N stage	ypN(+) vs ypN(−)	4.23	1.89–10.34	0.00040	4.15	1.68–11.05	0.0018
Lymphatic invasion	2, 3 vs. 0, 1	2.14	0.97–5.03	0.059
Vascular invasion	2, 3 vs. 0, 1	2.60	1.19–5.83	0.017	1.47	0.61–3.66	0.40
Radiation effect	Grades 2, 3 vs. 0–1	1.91	0.84–4.92	0.13
Radiation course	Short vs. long	1.72	0.76–3.78	0.19
Adjuvant chemotherapy	Yes vs. no	1.35	0.59–3.47	0.49
CA19-9	> 37.0 vs. ≤ 37.0 ng/ml	2.56	1.04–5.75	0.0041	2.00	0.76–4.91	0.15
CEA	> 5 vs. ≤ 5 ng/ml	2.69	1.14–7.36	0.022	1.81	0.73–5.17	0.21
PLR	> 150 vs. ≤ 150	1.07	0.47–2.32	0.87
PNI	≤ 51 vs. > 51	2.03	0.91–4.96	0.084
mGPS	1, 2 vs. 0	1.27	0.49–2.92	0.60
GNRI	≤ 104.25 vs. > 104.25	4.36	1.93–10.77	0.0003	4.37	1.88–11.10	0.00050

Note: Parameters with p < 0.05 in the univariate analysis were used for the multivariate analysis
HR hazard ratio, CI confidence interval, CA19-9 carbohydrate antigen 19-9, CEA carcinoembryonic antigen, PLR platelet-lymphocyte ratio, PNI prognostic nutrition index, mGPS modified Glasgow Prognostic score, GNRI geriatric nutritional risk index

ISSN: 1477-7819