Fig. 1

Identification of TMB-related miRNAs. a The heatmap of differentially expressed miRNAs (DE miRNAs). Each column represented each sample. The red dots in the heatmap represented upregulation, the green dots represented downregulation, and black dots represented miRNAs without differential expression. b Development of a TMB-related miRNA expression signature by the least absolute shrinkage and selection operator (LASSO) method. The optimal miRNAs with non-zero regression coefficients (λ) was selected by 10-fold cross-validation and “AUC” measure type