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Table 4 Multivariate analysis of clinical characteristics and CT features for discriminating LC from LM

From: Differentiation of primary lung cancer from solitary lung metastasis in patients with colorectal cancer: a retrospective cohort study

  Univariate P value Multivariate P value*
OR OR*
Age 1.04 (1.01–1.08) 0.009 1.05 (0.99–1.11) 0.102
Smoking 1.83 (1.02–3.30) 0.044 2.81 (0.91–8.64) 0.072
Index tumor location
 Colon cancer 2.47 (1.36–4.48) 0.009 1.41 (0.52–3.85) 0.503
 Rectal cancer Reference Reference
Index tumor stage
 Stages I–II 10.75 (5.42–21.33) < 0.001 21.70 (6.56–71.73) < 0.001
 Stages III–IV Reference Reference
Size of SPN 3.34 (1.92–5.83) < 0.001 2.01 (0.70–4.80) 0.197
Cranio-caudal location     
 Upper 1.48 (0.82–2.66) 0.189 1.33 (0.46–3.79) 0.600
 Non-upper Reference Reference
Central location
Central 0.50 (0.21–1.17) 0.110 2.11 (0.55–8.14) 0.280
Peripheral Reference Reference
Margin
 Spiculated margin 36.37 (11.71–112.99) < 0.001 8.34 (1.39–50.08) 0.020
 Lobulated margin 3.40 (1.39–8.35) 0.007 2.41 (0.66–8.89) 0.186
 Smooth margin Reference   Reference
Density
 Sub-solid density 62.64 (8.23–476.85) < 0.001 115.56 (9.96–1341.06) < 0.001
 Solid density Reference   Reference
Air bronchogram
 Yes 13.07 (5.33–32.05) < 0.001 5.32 (1.15–24.51) 0.032
 No Reference Reference
Cavitation
 Yes 1.32 (0.61–2.87) 0.482   
 No Reference
Pleural tags
 Yes 5.88 (3.08–11.22) < 0.001 2.41 (0.77–7.53) 0.131
 No Reference Reference
Pleural abutment
 Yes 1.21 (0.67–2.17) 0.529   
 No Reference
Background emphysema
 Yes 3.06 (1.40–6.71) 0.005 1.83 (0.55–6.06) 0.322
 No Reference Reference
  1. Data in parentheses are 95% confidence intervals. Each variable with a P value ≤ 0.25 in univariate analysis was analyzed in the multivariate model. All statistical analyses were performed using the logistic regression model. Note: significant ORs and P values are shown in bold
  2. CT computed tomography, LC lung cancer, LM lung metastases, OR odds ratio
  3. *Obtained by logistic regression model using all variables with a P value ≤ 0.25 in univariate analysis