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Table 4 Univariate analysis of influence factors of tumor recurrence in 42 patients with SMGC

From: Clinicopathological features and risk factors analysis of lymph node metastasis and long-term prognosis in patients with synchronous multiple gastric cancer

Factors

Patients (N)

Recurrence

P value

Positive

Negative

 

Gender

0.369#

 Male

32

5

27

 Female

10

3

7

Age (years)

0.709#

 < 65

23

5

18

 ≥65

19

3

16

Follow-up time, median (range, month)

27.5(3-33)

28.5(1-91)

0.1768

Postoperative hospital stay, median (range, day)

12.5(9-21)

12(8-55)

0.9009

Surgical methods

0.824#

 B I

5

1

4

 DG + R-Y

7

2

5

 TG + R-Y

30

5

25

BMI, median (range, Kg/m2)

21.6(19.5-27.8)

23.3(17.3-30.5)

0.6709

Neoadjuvant chemotherapy

0.479#

 Yes

3

1

2

 None

39

7

32

Hypertension

   

1.000#

 Yes

8

1

7

 None

34

7

27

Diabetes

   

1.000#

 Yes

3

0

3

 None

39

8

31

Number of primary tumors

   

0.158#

 Two

38

6

32

 Three

3

1

2

 Four

1

1

0

Tumor size

   

1.000#

 < 2 cm

2

0

2

 ≥2 cm

40

8

32

Histological type (Adenocarcinoma)a

   

0.635#

 Well-differentiated

8

2

6

 Poorly-differentiated

34

6

28

Consistency of histology

   

1.000#

 Positive

24

5

19

 Negative

18

3

15

Invasive depthb

   

0.308#

 T1

15

1

14

 T2

6

1

5

 T3-T4

21

6

15

Consistency of invasive depth

   

0.697#

 Positive

21

5

16

 Negative

21

3

18

Lymph node metastasis

   

0.045*#

 Yes

17

6

11

 None

25

2

23

Ulcer

   

1.000#

 Positive

38

7

31

 Negative

4

1

3

Lymphovascular cancer plug

   

0.162#

 Positive

8

3

5

 Negative

34

5

29

Nerve invasion

   

0.075#

 Positive

10

4

6

 Negative

32

4

28

Preoperative CEA, median (range, ng/ml)

1.96 (0.476–22.59)

2.36 (0.2–23.5)

0.8142

Preoperative CA19-9, median (range, U/ml)

7.3 (1.28–32.85)

10.31 (1.63–32.82)

0.3112

Preoperative AFP, median (range, ng/ml)

3.37 (1.18–8.25)

2.72 (0.947–5.92)

0.0791

Preoperative CA153, median (range, U/ml)

10.22 (4.92–16.59)

8.51 (3.44–20.82)

0.9523

Preoperative CA125, median (range, U/ml)

10.2 (7.09–17.2)

11.145 (3.28–27.61)

0.8395

Preoperative CA724, median (range, U/ml)

1.81 (0.699–4.06)

1.61 (0.2–141.1)

0.6102

Operation time, median (range, minute)

167.5 (110–240)

166.5 (102–330)

0.8218

Distant metastasis

0.19#

 Positive

1

1

0

 Negative

41

7

34

Postoperative complication

0.479#

 Yes

3

1

2

 None

39

7

32

Total

42

8

34

  1. It revealed that lymph node metastasis was the risk factor of tumor recurrence in patients with SMGC. Nerve invasion and preoperative AFP level might be the risk factors of recurrence, but without sufficient evidence
  2. SMGC synchronous multiple gastric cancer, BMI body mass index, B I Billroth I anastomosis, DG distal gastrectomy, TG total gastrectomy, R-Y Roux en-Y anastomosis
  3. *Statistically significant
  4. #Fisher’s exact test