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Table 2 Univariate analysis of influence factors of lymph node metastasis in 57 patients with SMGC

From: Clinicopathological features and risk factors analysis of lymph node metastasis and long-term prognosis in patients with synchronous multiple gastric cancer

Factors

Patients (N)

Lymph node metastasis

P value

Positive

Negative

 

Gender

0.2

 Male

45

17

28

 Female

12

7

5

Age (years)

0.426

 < 65

32

12

20

 ≥65

25

12

13

Surgical methods

0.537#

 B I

11

3

8

 DG + R-Y

9

4

5

 TG + R-Y

37

17

20

BMI, median (range, kg/m2)

-

23.25 (17.8–30.5)

21.6 (17.3–29.7)

0.4048

Neoadjuvant chemotherapy

1.000#

 Yes

5

2

3

 None

52

22

30

Number of primary tumors

   

0.49#

 Two

52

22

30

 Three

3

2

1

 Four

2

0

2

Tumor size

0.13#

 < 2 cm

4

0

4

 ≥2 cm

53

24

29

Histological type (Adenocarcinoma)a

0.017*#

 Well-differentiated

11

1

10

 Poorly- differentiated

46

23

23

Consistency of histology

   

0.548

 Positive

33

15

18

 Negative

24

9

15

Tumor pT stagingb

0.001*#

 pT1

20

3

17

 pT2

10

3

7

 pT3-T4

27

18

9

Consistency of tumor pT staging

0.203

 Positive

27

9

18

 Negative

30

15

15

Ulcer

0.631#

 Positive

53

23

30

 Negative

4

1

3

Lymphovascular cancer plug

0.000*

 Positive

13

12

1

 Negative

44

12

32

Nerve invasion

0.000*

 Positive

14

12

2

 Negative

43

12

31

Preoperative CEA, median (range, ng/ml)

2.51 (0.476–16.59)

2.32 (0.2–23.5)

0.6811

Preoperative CA19-9, median (range, U/ml)

12.055 (1.28–173.6)

8.82 (0.6–43.2)

0.1131

Preoperative AFP, median (range, ng/ml)

2.73 (1.26–8.25)

2.71 (0.947–6.94)

0.2103

Preoperative CA153, median (range, U/ml)

9.79 (3.44–20.82)

8 (4.67–20.6)

0.8183

Preoperative CA125, median (range, U/ml)

13.355 (4.46–39.09)

10.05 (3.28–18.87)

0.001*

Preoperative CA724, median (range, U/ml)

1.985 (0.699–8.35)

1.56 (0.2–141.1)

0.4285

Distant metastasis

0.173#

 Positive

2

2

0

 Negative

55

22

33

Total

57

24

33

  1. It indicated that histological type, tumor pT staging, lymphovascular cancer plug, nerve invasion, and preoperative CA125 level were the significant risk factors of lymph node metastasis in patients with SMGC
  2. SMGC synchronous multiple gastric cancer, BMI body mass index, B I Billroth I anastomosis, DG distal gastrectomy, TG total gastrectomy, R-Y Roux en-Y anastomosis
  3. *Statistically significant
  4. #Fisher’s exact test