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Table 4 Bivariate analysis of MACCE

From: Chemotherapy and adverse cardiovascular events in colorectal cancer patients undergoing surgical resection

Characteristics SHR 95% CI P value
Demographics
 Age 1.05 1.02-1.07 < 0.001
 Male sex 0.85 0.50-1.45 0.554
 Ethnicity    0.084
  Chinese Ref   -
  Malay 0.47 0.17-1.31 0.150
  Indian 1.82 0.63-5.27 0.271
  Others 2.79 0.88-8.82 0.081
Anthropometrics
 Body mass index (kg/m2) 0.99 0.94-1.04 0.619
Cardiovascular risk factors
 Smoking 1.57 0.78-3.15 0.208
 Hypertension 2.91 1.50-5.62 0.002
 Diabetes mellitus 3.17 1.87-5.37 < 0.001
 Insulin dependent diabetes 4.66 2.18-9.94 <  0.001
 Hyperlipidaemia 2.90 1.60-5.24 < 0001
 Any cardiovascular risk factor 4.30 1.54-12.04 0.005
 Number of cardiovascular risk factor    0.024
  0 Ref   
  1 3.20 0.35-29.07 0.302
  2 1.39 0.25-7.60 0.704
  3 4.68 1.65-13.25 0.004
  4 5.12 1.57-16.63 0.007
Charlson co-morbidity index    0.064
 ≤ 3 Ref   
 4-6 3.10 1.11-8.66 0.031
 ≥ 7 3.69 1.22-11.16 0.021
Concomitant conditions
 Prior cardiovascular disease 3.55 2.09-6.03 < 0.001
 Peripheral artery disease 3.68 1.57-8.67 0.003
 Chronic kidney disease 4.58 2.03-10.34 < 0.001
Cancer risk factors
Site of cancer    0.714
 Caecal Ref   
 Ascending 1.02 0.32-3.23 0.967
 Transverse 0.41 0.11-1.60 0.200
 Descending 0.41 0.09-1.78 0.234
 Sigmoid 0.70 0.25-1.96 0.493
 Rectosigmoid 0.65 0.18-2.32 0.510
 Rectum 0.68 0.23-2.01 0.486
T stage    0.842
 1 Ref   -
 2 1.07 0.37-3.13 0.900
 3 0.77 0.32-1.82 0.550
 4 0.87 0.34-2.20 0.765
N stage    0.200
 0 Ref   
 1 0.62 0.33-1.17 0.137
 2 0.56 0.22-1.40 0.213
M stage 0.21 0.05-0.87 0.032
Stage    0.143
 1 Ref   
 2 0.95 0.47-1.92 0.895
 3 0.74 0.35-1.59 0.451
 4 0.19 0.04-0.85 0.030
Grade    0.338
 Low/well-differentiated Ref   -
 Moderate 0.80 0.33-1.94 0.623
 Poor/high 0.20 0.02-1.69 0.141
Radiotherapy 0.62 0.25-1.55 0.307
Chemotherapy 0.27 0.14-0.51 < 0.001
  1. MACCE major adverse cardiac and cerebrovascular events, Ref reference, SHR subdistribution hazard ratio