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Table 1 Patient demographics and clinical characteristics

From: Chemotherapy and adverse cardiovascular events in colorectal cancer patients undergoing surgical resection

Characteristics Total (n = 412) Chemotherapy (n = 200) No chemotherapy (n = 212) P value
Demographics
 Age in years, mean (SD) 64.9 (11.2) 60.54 (9.7) 69.1 (11.0) < 0.001
 Male sex (n, %) 209 (50.7) 103 (51.5) 106 (50.0) 0.761
 Ethnicity (n, %)     0.747
  Chinese 332 (80.6) 157 (78.5) 175 (82.6)  
  Malay 59 (14.3) 31 (15.5) 28 (13.2)  
  Indian 12 (2.9) 7 (3.5) 5 (2.4)  
  Others 9 (2.2) 5 (2.5) 4 (1.9)  
Anthropometrics, mean (SD)
 Body mass index-baseline (kg/m2) 23.5 (4.4) 23.9 (0.3) 23.2 (0.3) 0.096
Cardiovascular risk factors (n, %)
 Smoking 46 (11.2) 22 (11.0) 24 (11.3) 0.918
 Hypertension 246 (59.7) 102 (51.0) 144 (67.9) < 0.001
 Diabetes mellitus 115 (27.9) 49 (24.5) 66 (31.3) 0.134
 HbA1c, %, mean (SD)   6.9 (1.5) 6.8 (1.6) 0.591
 Hyperlipidaemia 204 (49.5) 90 (45.0) 114 (53.8) 0.075
 Any cardiovascular risk factor (n, %) 312 (75.7) 139 (69.5) 173 (81.6) 0.004
 No. of cardiovascular risk factor (n, %)     0.007
  0 100 (24.3) 61 (30.5) 39 (18.4)  
  1 8 (1.9) 5 (2.5) 3 (1.4)  
  2 35 (8.5) 21 (10.5) 14 (6.6)  
  3 223 (54.1) 91 (45.5) 132 (62.3)  
  4 46 (11.2) 22 (11.0) 24 (11.3)  
Family history of cancer (n, %) 68 (16.5) 48 (24.0) 20 (9.4) < 0.001
Family history of colon cancer (n, %) 29 (7.0) 16 (8.0) 13 (6.1) 0.459
Family history of other cancer (n, %) 28 (6.8) 12 (6.0) 16 (7.6) 0.533
Charlson co-morbidity index (n, %)     < 0.001
 ≤ 3 80 (19.4) 54 (27.0) 26 (12.3)  
 4-6 252 (61.2) 97 (48.5) 155 (73.1)  
 ≥ 7 80 (19.4) 49 (24.5) 31 (14.6)  
Concomitant conditions (n, %)
 Prior cardiovascular disease 86 (20.9) 31 (15.5) 55 (25.9) 0.009
 Previous myocardial infarction 29 (7.0) 9 (4.5) 20 (9.4) 0.050
 Previous percutaneous coronary intervention 25 (6.1) 10 (5.0) 15 (7.8) 0.378
 Previous coronary artery bypass grafting 11 (2.7) 5 (2.5) 6 (2.8) 0.835
 Stroke/transient ischaemic attack 24 (5.8) 4 (2.0) 20 (9.4) 0.001
 Peripheral artery disease 12 (2.9) 3 (1.5) 9 (4.3) 0.098
 Atrial fibrillation 18 (4.3) 5 (2.5) 13 (6.1) 0.071
 Chronic kidney disease 16 (3.9) 2 (1.0) 14 (6.6) 0.003
Cancer characteristics
Site (n, %)     0.004
 Caecal 20 (4.9) 7 (3.5) 13 (6.1)  
 Ascending 41 (10.0) 14 (7.0) 27 (12.7)  
 Transverse 49 (11.9) 19 (9.5) 30 (14.2)  
 Descending 36 (8.7) 20 (10.0) 16 (7.6)  
 Sigmoid 140 (34.0) 67 (33.5) 73 (34.4)  
 Rectosigmoid 38 (9.2) 15 (7.5) 23 (10.9)  
 Rectum 88 (21.4) 58 (29.0) 30 (14.2)  
T stage (n, %)     < 0.001
 1 38 (9.2) 7 (3.5) 31 (14.6)  
 2 41 (10.0) 18 (9.0) 23 (10.9)  
 3 221 (53.6) 103 (51.5) 118 (55.7)  
 4 112 (27.2) 72 (36.0) 40 (18.9)  
N stage (n, %)     < 0.001
 0 229 (55.6) 58 (29.0) 171 (80.7)  
 1 129 (31.3) 96 (48.0) 33 (15.6)  
 2 54 (13.1) 46 (23.0) 8 (3.8)  
 3     
M stage (n, %)     < 0.001
 0 353 (85.7) 149 (74.5) 204 (96.2)  
 1 59 (14.3) 51 (25.5) 8 (3.8)  
Stage (n, %)     < 0.001
 1 64 (15.5) 11 (5.5) 53 (25.0)  
 2 155 (37.6) 39 (19.5) 116 (54.7)  
 3 134 (32.5) 99 (49.5) 35 (16.5)  
 4 59 (14.3) 51 (25.5) 8 (3.8)  
Histological cell type (n, %)     0.460
 Adenocarcinoma 399 (96.8) 195 (97.5) 204 (96.2)  
 Others 13 (3.2) 5 (2.5) 8 (3.8)  
Grade (n, %)     0.038
 Low/well differentiated 29 (7.0) 11 (5.5) 18 (8.5)  
 Moderate 356 (86.4) 170 (85.0) 186 (87.7)  
 Poor/high 27 (6.6) 19 (9.5) 8 (3.8)  
Margin (n, %)     0.025
 Positive 11 (2.7) 9 (4.5) 2 (0.9)  
 Negative 401 (97.3) 191 (95.5) 210 (99.1)  
Radiotherapy (n, %) 55 (13.4) 53 (26.5) 2 (0.9) < 0.001
  1. HbA1c haemogloblin A1c; M metastases; N nodes; SD standard deviation; T tumour