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Table 2 Meta-analysis results of this study

From: CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies

VariablesSample sizeDominant comparisonRecessive comparisonOver-dominant comparisonAllele comparison
M/M vs. M/m + m/mm/m vs. M/M + M/mM/m vs. M/M + m/mM vs. m
p valueOR (95%CI)p valueOR (95%CI)p valueOR (95%CI)p valueOR (95%CI)
rs231775
 Overall9890/14,2380.910.99 (0.89–1.11)0.130.86 (0.71–1.05)0.031.06 (1.00–1.12)0.221.06 (0.96–1.17)
 Esophageal cancer1588/18270.470.87 (0.60–1.26)0.710.96 (0.77–1.20)0.671.05 (0.83–1.35)0.570.93 (0.93–1.19)
 Gastric cancer2079/37990.841.02 (0.81–1.29)0.650.92 (0.66–1.30)0.271.07 (0.95–1.19)0.161.14 (0.95–1.37)
 Colorectal cancer3042/44240.641.04 (0.88–1.23)0.0070.55 (0.35–0.84)0.0061.14 (1.04–1.25)0.091.16 (0.98–1.38)
 Liver cancer1971/24640.821.04 (0.76–1.41)0.571.13 (0.75–1.70)0.410.95 (0.84–1.07)0.981.00 (0.77–1.31)
 Pancreatic cancer970/1577< 0.00010.67 (0.57–0.79)0.00011.67 (1.29–2.16)0.031.20 (1.02–1.42)< 0.00010.73 (0.64–0.82)
rs4553808
 Overall456/8430.040.77 (0.60–0.98)0.0030.52 (0.34–0.81)< 0.00011.73 (1.34–2.24)0.870.98 (0.81–1.19)
 Gastric cancer251/4500.200.80 (0.57–1.12)0.030.56 (0.33–0.95)0.0021.77 (1.23–2.55)0.861.02 (0.78–1.34)
rs5742909
 Overall1302/16660.760.94 (0.63–1.40)0.421.22 (0.75–1.99)0.421.15 (0.82–1.62)0.580.87 (0.54–1.41)
 Gastric cancer344/5580.041.58 (1.01–2.48)0.140.40 (0.12–1.36)0.460.74 (0.33–1.66)0.011.69 (1.12–2.56)
 Colorectal cancer404/4960.450.88 (0.63–1.23)0.660.81 (0.32–2.08)0.331.19 (0.84–1.68)0.150.58 (0.28–1.21)
rs3087243
 Overall4768/59370.720.96 (0.79–1.17)0.660.92 (0.64–1.33)0.701.03 (0.87–1.23)0.900.99 (0.84–1.17)
 Gastric cancer865/23020.530.95 (0.81–1.12)0.140.69 (0.43–1.13)0.231.11 (0.94–1.31)0.951.00 (0.86–1.15)
 Colorectal cancer2774/21020.451.14 (0.81–1.59)0.490.75 (0.32–1.72)0.580.92 (0.69–1.23)0.391.15 (0.84–1.56)
 Liver cancer1129/15330.040.76 (0.58–0.99)0.0061.43 (1.11–1.85)0.511.15 (0.76–1.73)< 0.00010.78 (0.69–0.88)
rs733618
 Overall3466/57810.100.81 (0.64–1.04)0.120.91 (0.80–1.02)0.041.27 (1.01–1.59)0.160.88 (0.74–1.05)
 Gastric cancer1095/25090.130.65 (0.37–1.14)0.230.88 (0.72–1.08)0.081.60 (0.95–2.70)0.180.77 (0.52–1.13)
 Colorectal cancer1089/14890.891.01 (0.85–1.20)0.870.98 (0.79–1.22)0.991.00 (0.85–1.18)0.050.89 (0.79–1.00)
 Liver cancer671/11260.500.70 (0.25–1.96)0.180.83 (0.62–1.09)0.381.50 (0.60–3.73)0.510.73 (0.29–1.85)
rs16840252
 Overall2364/42960.641.05 (0.85–1.31)0.940.99 (0.73–1.34)0.440.91 (0.72–1.16)0.891.01 (0.83–1.24)
 Gastric cancer809/20750.840.98 (0.81–1.19)0.191.22 (0.90–1.66)0.890.97 (0.68–1.40)0.390.93 (0.78–1.10)
  1. Abbreviations: OR odds ratio, CI confidence interval, NA not available