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Table 1 The characteristics of included studies for this meta-analysis

From: CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies

First author, yearCountryEthnicityType of diseaseSample sizeGenotypes (wtwt/wtmt/mtmt)P value for HWENOS score
CasesControls
rs231775 A/G
 Cai 2011*ChinaEast AsianEsophageal cancer125/25030/68/2770/133/470.2488
 Cheng 2006*TaiwanEast AsianGastric cancer62/25034/26/2119/102/290.3237
 Cheng 2011*ChinaEast AsianEsophageal cancer205/20554/105/4690/79/360.0137
 Cozar 2007*SpainCaucasianColorectal cancer96/17646/44/678/77/210.7668
 Cui 2012*ChinaEast AsianColorectal cancer128/20573/46/984/68/53< 0.0017
 Cui 2016*ChinaEast AsianLiver cancer96/20552/37/764/96/450.4297
 Dilmec 2008*TurkeyMixedColorectal cancer56/16236/19/1108/43/110.0287
 Fan 2012*ChinaEast AsianColorectal cancer291/352123/146/22170/138/440.0598
 Ge 2015*ChinaEast AsianColorectal cancer572/626296/242/34292/284/500.0947
 Gu 2010*ChinaEast AsianLiver cancer367/407150/166/51183/179/450.9028
 Hadinia 2007*IranMixedColorectal cancer105/19052/47/6117/59/140.0978
 Hadinia 2007*IranMixedGastric cancer46/19027/13/6117/59/140.0978
 Hou 2010*ChinaEast AsianGastric cancer205/26294/70/41107/100/55< 0.0017
 Hu 2010*ChinaEast AsianLiver cancer853/854367/380/106399/376/790.4768
 Lang 2012*ChinaEast AsianPancreatic cancer602/651208/312/82263/326/620.0068
 Li 2011*ChinaEast AsianColorectal cancer248/380120/120/8171/167/420.8988
 Liu 2015*ChinaEast AsianLiver cancer80/7829/36/1538/33/70.9667
 Liu 2015*ChinaEast AsianEsophageal cancer629/686307/254/43310/296/580.2847
 Liu 2019*ChinaEast AsianGastric cancer487/1470228/215/44698/631/1410.9267
 Mahajan 2008*PolandCaucasianGastric cancer301/41189/153/59152/189/700.3937
 Qi 2010*ChinaEast AsianColorectal cancer124/40760/60/4183/179/450.9028
 Solerio 2005*ItalyCaucasianColorectal cancer132/23876/43/13128/91/190.6188
 Sun 2008*ChinaEast AsianGastric cancer530/530235/235/60282/209/390.9748
 Sun 2008*ChinaEast AsianEsophageal cancer629/686307/254/43310/290/580.3988
 Tang 2016*ChinaEast AsianGastric cancer330/590155/153/22278/264/480.1798
 Wang 2015*ChinaEast AsianColorectal cancer311/389121/147/43141/147/101< 0.0017
 Yang 2012*ChinaEast AsianPancreatic cancer368/926140/178/50482/374/700.8288
 Yang 2015*ChinaEast AsianColorectal cancer240/147195/39/6102/40/50.6627
 Yang 2019*ChinaEast AsianLiver cancer575/920290/221/64444/389/870.8938
 Yuan 2012*ChinaEast AsianGastric cancer118/9665/45/830/45/210.5957
 Zou 2018*ChinaEast AsianColorectal cancer979/1299417/443/119621/563/1150.4308
rs4553808 A/G
 Cui 2016*ChinaEast AsianLiver cancer96/20533/56/779/96/300.9247
 Hadinia 2007*IranMixedColorectal cancer109/18874/33/2145/36/70.027
 Hadinia 2007*IranMixedGastric cancer46/18837/9/0145/36/70.027
 Hou 2010*ChinaEast AsianGastric cancer205/262112/71/22163/54/45< 0.0017
rs5742909 C/T
 Cheng 2006*TaiwanEast AsianGastric cancer62/25059/3/0209/40/10.3237
 Dilmec 2008*TurkeyMixedColorectal cancer56/16248/8/0149/12/10.1857
 Hadinia 2007*IranMixedGastric cancer46/18738/8/0159/24/40.0148
 Hadinia 2007*IranMixedColorectal cancer108/18791/16/1159/24/40.0137
 Li 2009*ChinaEast AsianGastric cancer236/121206/27/399/17/50.0017
 Wang 2019*ChinaEast AsianLiver cancer554/612360/170/24466/134/120.5178
 Yang 2015*ChinaEast AsianColorectal cancer240/147150/82/894/48/50.7077
rs3087243 CT60AG
 Cheng 2006*TaiwanEast AsianGastric cancer62/25039/20/3154/79/170.1267
 Cozar 2007*SpainCaucasianColorectal cancer95/17520/56/1940/88/470.9237
 Ge 2015*ChinaEast AsianColorectal cancer1699/6271258/425/16413/198/160.1748
 Liu 2019*ChinaEast AsianGastric cancer487/1472302/172/13958/462/520.6868
 Tang 2016*ChinaEast AsianGastric cancer316/580213/98/5382/182/160.3028
 Wang 2019*ChinaEast AsianLiver cancer554/612200/238/116240/274/980.1858
 Yang 2019*ChinaEast AsianLiver cancer575/921325/221/29609/282/300.7038
 Zou 2018*ChinaEast AsianColorectal cancer980/1300637/296/47850/408/420.4108
rs733618 T/C
 Cui 2016*ChinaEast AsianLiver cancer96/20572/24/0181/24/00.3737
 Hadinia 2007*IranMixedColorectal cancer109/18997/12/0165/24/00.3517
 Hadinia 2007*IranMixedGastric cancer83/18942/41/0165/24/00.3517
 Hou 2010*ChinaEast AsianGastric cancer205/26275/111/1993/139/300.0417
 Liu 2019*ChinaEast AsianGastric cancer487/1472168/242/77525/685/2620.1398
 Tang 2014*ChinaEast AsianEsophageal cancer611/657210/300/101228/314/1150.7008
 Tang 2016*ChinaEast AsianGastric cancer320/586102/163/55198/282/1060.7498
 Yang 2019*ChinaEast AsianLiver cancer575/921217/268/90320/432/1690.2758
 Zou 2018*ChinaEast AsianColorectal cancer980/1300346/464/170458/613/2290.3358
rs16840252 C/T
 Liu 2019*ChinaEast AsianGastric cancer492/1472381/94/71130/329/130.0398
 Tang 2016*ChinaEast AsianGastric cancer317/603235/78/4460/130/130.2938
 Yang 2019*ChinaEast AsianLiver cancer575/921477/93/5707/205/90.1648
 Zou 2018*ChinaEast AsianColorectal cancer980/1300742/223/151006/283/110.0658
  1. Abbreviations: wt wild type, mt mutant type, HWE Hardy-Weinberg equilibrium, NOS Newcastle-Ottawa scale, NA not available
  2. *Full manuscript of all eligible studies can be accessed at https://osf.io