Table 1 The characteristics of included studies for this meta-analysis
First author, year | Country | Ethnicity | Type of disease | Sample size | Genotypes (wtwt/wtmt/mtmt) | P value for HWE | NOS score | |
|---|---|---|---|---|---|---|---|---|
Cases | Controls | |||||||
rs231775 A/G | ||||||||
Cai 2011* | China | East Asian | Esophageal cancer | 125/250 | 30/68/27 | 70/133/47 | 0.248 | 8 |
Cheng 2006* | Taiwan | East Asian | Gastric cancer | 62/250 | 34/26/2 | 119/102/29 | 0.323 | 7 |
Cheng 2011* | China | East Asian | Esophageal cancer | 205/205 | 54/105/46 | 90/79/36 | 0.013 | 7 |
Cozar 2007* | Spain | Caucasian | Colorectal cancer | 96/176 | 46/44/6 | 78/77/21 | 0.766 | 8 |
Cui 2012* | China | East Asian | Colorectal cancer | 128/205 | 73/46/9 | 84/68/53 | < 0.001 | 7 |
Cui 2016* | China | East Asian | Liver cancer | 96/205 | 52/37/7 | 64/96/45 | 0.429 | 7 |
Dilmec 2008* | Turkey | Mixed | Colorectal cancer | 56/162 | 36/19/1 | 108/43/11 | 0.028 | 7 |
Fan 2012* | China | East Asian | Colorectal cancer | 291/352 | 123/146/22 | 170/138/44 | 0.059 | 8 |
Ge 2015* | China | East Asian | Colorectal cancer | 572/626 | 296/242/34 | 292/284/50 | 0.094 | 7 |
Gu 2010* | China | East Asian | Liver cancer | 367/407 | 150/166/51 | 183/179/45 | 0.902 | 8 |
Hadinia 2007* | Iran | Mixed | Colorectal cancer | 105/190 | 52/47/6 | 117/59/14 | 0.097 | 8 |
Hadinia 2007* | Iran | Mixed | Gastric cancer | 46/190 | 27/13/6 | 117/59/14 | 0.097 | 8 |
Hou 2010* | China | East Asian | Gastric cancer | 205/262 | 94/70/41 | 107/100/55 | < 0.001 | 7 |
Hu 2010* | China | East Asian | Liver cancer | 853/854 | 367/380/106 | 399/376/79 | 0.476 | 8 |
Lang 2012* | China | East Asian | Pancreatic cancer | 602/651 | 208/312/82 | 263/326/62 | 0.006 | 8 |
Li 2011* | China | East Asian | Colorectal cancer | 248/380 | 120/120/8 | 171/167/42 | 0.898 | 8 |
Liu 2015* | China | East Asian | Liver cancer | 80/78 | 29/36/15 | 38/33/7 | 0.966 | 7 |
Liu 2015* | China | East Asian | Esophageal cancer | 629/686 | 307/254/43 | 310/296/58 | 0.284 | 7 |
Liu 2019* | China | East Asian | Gastric cancer | 487/1470 | 228/215/44 | 698/631/141 | 0.926 | 7 |
Mahajan 2008* | Poland | Caucasian | Gastric cancer | 301/411 | 89/153/59 | 152/189/70 | 0.393 | 7 |
Qi 2010* | China | East Asian | Colorectal cancer | 124/407 | 60/60/4 | 183/179/45 | 0.902 | 8 |
Solerio 2005* | Italy | Caucasian | Colorectal cancer | 132/238 | 76/43/13 | 128/91/19 | 0.618 | 8 |
Sun 2008* | China | East Asian | Gastric cancer | 530/530 | 235/235/60 | 282/209/39 | 0.974 | 8 |
Sun 2008* | China | East Asian | Esophageal cancer | 629/686 | 307/254/43 | 310/290/58 | 0.398 | 8 |
Tang 2016* | China | East Asian | Gastric cancer | 330/590 | 155/153/22 | 278/264/48 | 0.179 | 8 |
Wang 2015* | China | East Asian | Colorectal cancer | 311/389 | 121/147/43 | 141/147/101 | < 0.001 | 7 |
Yang 2012* | China | East Asian | Pancreatic cancer | 368/926 | 140/178/50 | 482/374/70 | 0.828 | 8 |
Yang 2015* | China | East Asian | Colorectal cancer | 240/147 | 195/39/6 | 102/40/5 | 0.662 | 7 |
Yang 2019* | China | East Asian | Liver cancer | 575/920 | 290/221/64 | 444/389/87 | 0.893 | 8 |
Yuan 2012* | China | East Asian | Gastric cancer | 118/96 | 65/45/8 | 30/45/21 | 0.595 | 7 |
Zou 2018* | China | East Asian | Colorectal cancer | 979/1299 | 417/443/119 | 621/563/115 | 0.430 | 8 |
rs4553808 A/G | ||||||||
Cui 2016* | China | East Asian | Liver cancer | 96/205 | 33/56/7 | 79/96/30 | 0.924 | 7 |
Hadinia 2007* | Iran | Mixed | Colorectal cancer | 109/188 | 74/33/2 | 145/36/7 | 0.02 | 7 |
Hadinia 2007* | Iran | Mixed | Gastric cancer | 46/188 | 37/9/0 | 145/36/7 | 0.02 | 7 |
Hou 2010* | China | East Asian | Gastric cancer | 205/262 | 112/71/22 | 163/54/45 | < 0.001 | 7 |
rs5742909 C/T | ||||||||
Cheng 2006* | Taiwan | East Asian | Gastric cancer | 62/250 | 59/3/0 | 209/40/1 | 0.323 | 7 |
Dilmec 2008* | Turkey | Mixed | Colorectal cancer | 56/162 | 48/8/0 | 149/12/1 | 0.185 | 7 |
Hadinia 2007* | Iran | Mixed | Gastric cancer | 46/187 | 38/8/0 | 159/24/4 | 0.014 | 8 |
Hadinia 2007* | Iran | Mixed | Colorectal cancer | 108/187 | 91/16/1 | 159/24/4 | 0.013 | 7 |
Li 2009* | China | East Asian | Gastric cancer | 236/121 | 206/27/3 | 99/17/5 | 0.001 | 7 |
Wang 2019* | China | East Asian | Liver cancer | 554/612 | 360/170/24 | 466/134/12 | 0.517 | 8 |
Yang 2015* | China | East Asian | Colorectal cancer | 240/147 | 150/82/8 | 94/48/5 | 0.707 | 7 |
rs3087243 CT60AG | ||||||||
Cheng 2006* | Taiwan | East Asian | Gastric cancer | 62/250 | 39/20/3 | 154/79/17 | 0.126 | 7 |
Cozar 2007* | Spain | Caucasian | Colorectal cancer | 95/175 | 20/56/19 | 40/88/47 | 0.923 | 7 |
Ge 2015* | China | East Asian | Colorectal cancer | 1699/627 | 1258/425/16 | 413/198/16 | 0.174 | 8 |
Liu 2019* | China | East Asian | Gastric cancer | 487/1472 | 302/172/13 | 958/462/52 | 0.686 | 8 |
Tang 2016* | China | East Asian | Gastric cancer | 316/580 | 213/98/5 | 382/182/16 | 0.302 | 8 |
Wang 2019* | China | East Asian | Liver cancer | 554/612 | 200/238/116 | 240/274/98 | 0.185 | 8 |
Yang 2019* | China | East Asian | Liver cancer | 575/921 | 325/221/29 | 609/282/30 | 0.703 | 8 |
Zou 2018* | China | East Asian | Colorectal cancer | 980/1300 | 637/296/47 | 850/408/42 | 0.410 | 8 |
rs733618 T/C | ||||||||
Cui 2016* | China | East Asian | Liver cancer | 96/205 | 72/24/0 | 181/24/0 | 0.373 | 7 |
Hadinia 2007* | Iran | Mixed | Colorectal cancer | 109/189 | 97/12/0 | 165/24/0 | 0.351 | 7 |
Hadinia 2007* | Iran | Mixed | Gastric cancer | 83/189 | 42/41/0 | 165/24/0 | 0.351 | 7 |
Hou 2010* | China | East Asian | Gastric cancer | 205/262 | 75/111/19 | 93/139/30 | 0.041 | 7 |
Liu 2019* | China | East Asian | Gastric cancer | 487/1472 | 168/242/77 | 525/685/262 | 0.139 | 8 |
Tang 2014* | China | East Asian | Esophageal cancer | 611/657 | 210/300/101 | 228/314/115 | 0.700 | 8 |
Tang 2016* | China | East Asian | Gastric cancer | 320/586 | 102/163/55 | 198/282/106 | 0.749 | 8 |
Yang 2019* | China | East Asian | Liver cancer | 575/921 | 217/268/90 | 320/432/169 | 0.275 | 8 |
Zou 2018* | China | East Asian | Colorectal cancer | 980/1300 | 346/464/170 | 458/613/229 | 0.335 | 8 |
rs16840252 C/T | ||||||||
Liu 2019* | China | East Asian | Gastric cancer | 492/1472 | 381/94/7 | 1130/329/13 | 0.039 | 8 |
Tang 2016* | China | East Asian | Gastric cancer | 317/603 | 235/78/4 | 460/130/13 | 0.293 | 8 |
Yang 2019* | China | East Asian | Liver cancer | 575/921 | 477/93/5 | 707/205/9 | 0.164 | 8 |
Zou 2018* | China | East Asian | Colorectal cancer | 980/1300 | 742/223/15 | 1006/283/11 | 0.065 | 8 |