Table 4 Meta-analysis results for CYP2E1 rs2031920
Genotype and subgroup | Number of studies | Test of association | Test of heterogeneity | P of Egger’s test | ||
|---|---|---|---|---|---|---|
OR (95% CI) | Z (P value) | I2 (%) | Phet | |||
CT + TT vs. CC | ||||||
 Overall | 12 | 0.82 (0.53–1.26) | 0.358 | 83.2 | 0.000 | 0.843 |
 Chinese | 8 | 0.69 (0.37–1.31) | 0.259 | 87.0 | 0.000 |  |
 Japanese | 3 | 1.08 (0.82–1.42) | 0.587 | 0 | 0.698 |  |
 Korean | 1 | 1.76 (0.72–4.30) | 0.215 | NA | NA |  |
 Population-based studies | 2 | 0.31 (0.05–1.98) | 0.214 | 95.2 | 0.000 |  |
 Hospital-based studies | 10 | 0.97 (0.68–1.39) | 0.871 | 68.7 | 0.001 |  |
TT vs. CT + CC | ||||||
 Overall | 9 | 0.72 (0.49–1.06) | 0.096 | 0 | 0.921 | 0.714 |
 Chinese | 7 | 0.69 (0.44–1.08) | 0.107 | 0 | 0.803 |  |
 Japanese | 1 | 0.84 (0.35–2.01) | 0.697 | NA | NA |  |
 Korean | 1 | 0.70 (0.13–3.82) | 0.684 | NA | NA |  |
 Population-based studies | 2 | 0.80 (0.41–1.57) | 0.520 | 0 | 0.717 |  |
 Hospital-based studies | 7 | 0.68 (0.43–1.10) | 0.115 | 0 | 0.818 |  |
TT vs. CC | ||||||
 Overall | 9 | 0.54 (0.27–1.08) | 0.079 | 59.0 | 0.012 | 0.523 |
 Chinese | 7 | 0.47 (0.19–1.16) | 0.102 | 65.1 | 0.009 |  |
 Japanese | 1 | 0.87 (0.36–2.11) | 0.761 | NA | NA |  |
 Korean | 1 | 0.86 (0.16–4.73) | 0.861 | NA | NA |  |
 Population-based studies | 2 | 0.25 (0.04–1.67) | 0.153 | 84.9 | 0.010 |  |
 Hospital-based studies | 7 | 0.70 (0.37–1.31) | 0.266 | 27.2 | 0.221 |  |
CT vs. CC | ||||||
 Overall | 9 | 0.97 (0.67–1.41) | 0.886 | 70.6 | 0.001 | 0.595 |
 Chinese | 7 | 0.89 (0.56–1.42) | 0.624 | 75.2 | 0.000 |  |
 Japanese | 1 | 1.11 (0.75–1.64) | 0.607 | NA | NA |  |
 Korean | 1 | 2.06 (0.77–5.52) | 0.151 | NA | NA |  |
 Population-based studies | 2 | 1.03 (0.69–1.52) | 0.899 | 31.4 | 0.227 |  |
 Hospital-based studies | 7 | 1.00 (0.59–1.68) | 0.994 | 76.6 | 0.000 |  |