Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis

Table 3 Meta-analysis results for ALDH2 rs671

Genotype and subgroup	Number of studies	Test of association		Test of heterogeneity		P of Egger’s test
Genotype and subgroup	Number of studies	OR (95% CI)	Z (P value)	I² (%)	P_het	P of Egger’s test
AA + GA vs. GG
Overall	10	1.10 (0.90–1.35)	0.369	59.6	0.008	0.430
HWE (yes)	9	1.08 (0.86–1.35)	0.527	62.0	0.007
HWE (no)	1	1.32 (0.89–1.96)	0.171	NA	NA
Chinese	4	1.03 (0.87–1.21)	0.770	17.7	0.303
Japanese	6	1.21 (0.81–1.80)	0.362	71.5	0.004
Population-based studies	4	0.98 (0.80–1.20)	0.859	24.1	0.267
Hospital-based studies	6	1.24 (0.88–1.75)	0.210	68.9	0.007
AA vs. GA + GG
Overall	9	1.19 (0.82–1.73)	0.357	58.2	0.014	0.866
HWE (yes)	8	1.13 (0.75–1.71)	0.562	61.2	0.012
HWE (no)	1	1.67 (0.85–3.28)	0.137	NA	NA
Chinese	4	1.19 (0.93–1.52)	0.165	0	0.589
Japanese	5	1.00 (0.41–2.42)	1.000	76.8	0.002
Population-based studies	4	1.10 (0.82–1.49)	0.521	8.6	0.350
Hospital-based studies	5	1.26 (0.62–2.56)	0.526	73.7	0.004
AA vs. GG						0.289
Overall	8	1.08 (0.87–1.34)	0.509	37.1	0.133
HWE (yes)	7	1.02 (0.81–1.28)	0.892	33.6	0.171
HWE (no)	1	1.77 (0.89–3.54)	0.104	NA	NA
Chinese	4	1.18 (0.92–1.52)	0.191	0	0.452
Japanese	4	0.82 (0.54–1.26)	0.373	58.0	0.067
Population-based studies	4	1.08 (0.74–1.57)	0.690	24.7	0.263
Hospital-based studies	4	1.00 (0.54–1.85)	0.992	58.1	0.067
GA vs. GG
Overall	9	1.06 (0.86–1.31)	0.569	54.2	0.026	0.464
HWE (yes)	8	1.05 (0.83–1.32)	0.697	58.7	0.018
HWE (no)	1	1.20 (0.78–1.85)	0.403	NA	NA
Chinese	4	0.99 (0.85–1.14)	0.833	0	0.452
Japanese	5	1.21 (0.78–1.89)	0.395	70.0	0.010
Population-based studies	4	0.97 (0.83–1.13)	0.669	0	0.452
Hospital-based studies	5	1.22 (0.83–1.78)	0.305	69.2	0.011

ISSN: 1477-7819