Table 4 Univariate and multivariate Cox analysis for OS

Gender

0.872

0.693

 Male

Reference

Reference

 Female

0.941 (0.47–1.69)

1.013 (0.341–1.592)

Age (years)

0.443

0.565

 < 18

Reference

Reference

 ≥ 18

1.152 (0.957–1.344)

1.094 (0.982–1.415)

Tumor location

0.465

0.621

 Extremities

Reference

Reference

 Non-extremities

1.123 (0.892–1.458)

1.075 (0.917–1.273)

Tumor size (cm)

0.026

0.373

< 10.5

Reference

Reference

≥ 10.5

2.378 (1.087–3.346)

1.426 (0.719–2.765)

Histological type

0.052

0.124

 Well-differentiated

Reference

Reference

 Poorly differentiated

1.463 (1.275–2.897)

1.205 (0.894–2.319)

Enneking stage

< 0.001

< 0.001

 I/II

Reference

Reference

 III

3.140 (1.021–7.361)

3.820 (0.172–8.909)

Pathological fracture

0.039

0.318

 No

Reference

Reference

 Yes

1.222 (1.077–8.418)

1.219 (0.893–7.029)

Local recurrence

0.033

< 0.001

 No

Reference

Reference

 Yes

3.563 (1.359–6.379)

4.162 (1.085–9.153)

Metastasis

< 0.001

< 0.001

 No

Reference

Reference

 Yes

5.378 (1.359–6.379)

6.482 (1.985–13.647)

Neoadjuvant CT

0.447

0.624

 No

Reference

Reference

 Yes

0.897 (0.296–1.854)

0.845 (0.404–1.532)

NLR

< 0.001

< 0.001

 Low (≤ 2.96)

Reference

Reference

 High (> 2.96)

3.197 (1.786–6.454)

3.986 (0.781–6.239)

LMR

0.004

0.057

 Low (≤ 4.44)

Reference

Reference

 High (> 4.44)

0.786 (0.457–2.345)

0.855 (0.753–1.783)

Albumin

0.037

0.126

 Low (< 4 mg/dL)

Reference

Reference

 High (≥ 4 mg/dL)

0.887 (0.768–1.508)

0.975 (0.684–1.651)

TC

0.782

0.651

 Low (≤ 180 mg/dL)

Reference

Reference

 High (> 180 mg/dL)

0.898 (0.654–1.317)

1.056 (0.737–2.249)

NPS Group

 1

Reference

Reference

 2

4.323 (0.996–9.852)

< 0.001

5.873(1.031–6.428)

< 0.001

 3

7.073 (1.188–15.124)

< 0.001

6.547(1.153–13.624)

< 0.001