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Table 3 Identification of the prognosis-associated factors in colon cancer (the TCGA samples) using Cox regression analysis

From: Identification of a prognostic gene signature of colon cancer using integrated bioinformatics analysis

Clinical characteristics TCGA (N = 432) Univariate Multivariate
HR (95% CI) p value HR (95% CI) p value
Age (years, mean ± sd) 66.78 ± 12.88 1.018 (1.001–1.035) 3.408E−02 1.047 (1.021–1.073) 3.510E−04
Gender (male/female) 230/202 1.077 (0.719–1.610) 7.189E−01
Pathologic M (M0/M1/–) 319/59/54 4.536 (2.851–7.218) 2.649E−12 1.501 (0.373–6.036) 5.671E− 01
Pathologic N (N0/N1/N2) 254/101/77 2.088 (1.648–2.644) 1.342E−10 1.614 (0.839–3.103) 1.514E−01
Pathologic T(T1/T2/T3/T4) 11/75/296/50 2.658 (1.775–3.979) 1.116E−06 3.561 (1.781–7.121) 3.280E−04
Pathologic stage (I/II/III/IV/–) 73/167/123/59/10 2.181 (1.719–2.767) 3.376E−11 1.123 (0.373–3.378) 8.362E−01
Colon polyps history (yes/no/–) 128/239/65 0.731 (0.426–1.255) 2.537E− 01
Lymphatic invasion (yes/no/–) 150/241/41 2.150 (1.392–3.320) 4.125E− 04 0.922 (0.489–1.737) 8.024E− 01
Recurrence (yes/no) 78/292/62 2.567 (1.636–4.029) 2.113E−05 1.881 (1.050–3.369) 3.363E− 02
PS model status (high/low) 216/216 3.287 (2.082–5.189) 4.096E−08 2.737 (1.447–5.178) 1.970E−03
Vital status (dead/alive) 96/336
Overall survival time (months, mean ± sd) 29.44 ± 25.43
  1. HR hazard ratio, CI confidential interval, TCGA The Cancer Genome Atlas, SD standard deviation