Skip to main content

Table 3 Identification of the prognosis-associated factors in colon cancer (the TCGA samples) using Cox regression analysis

From: Identification of a prognostic gene signature of colon cancer using integrated bioinformatics analysis

Clinical characteristics

TCGA (N = 432)

Univariate

Multivariate

HR (95% CI)

p value

HR (95% CI)

p value

Age (years, mean ± sd)

66.78 ± 12.88

1.018 (1.001–1.035)

3.408E−02

1.047 (1.021–1.073)

3.510E−04

Gender (male/female)

230/202

1.077 (0.719–1.610)

7.189E−01

–

–

Pathologic M (M0/M1/–)

319/59/54

4.536 (2.851–7.218)

2.649E−12

1.501 (0.373–6.036)

5.671E− 01

Pathologic N (N0/N1/N2)

254/101/77

2.088 (1.648–2.644)

1.342E−10

1.614 (0.839–3.103)

1.514E−01

Pathologic T(T1/T2/T3/T4)

11/75/296/50

2.658 (1.775–3.979)

1.116E−06

3.561 (1.781–7.121)

3.280E−04

Pathologic stage (I/II/III/IV/–)

73/167/123/59/10

2.181 (1.719–2.767)

3.376E−11

1.123 (0.373–3.378)

8.362E−01

Colon polyps history (yes/no/–)

128/239/65

0.731 (0.426–1.255)

2.537E− 01

–

–

Lymphatic invasion (yes/no/–)

150/241/41

2.150 (1.392–3.320)

4.125E− 04

0.922 (0.489–1.737)

8.024E− 01

Recurrence (yes/no)

78/292/62

2.567 (1.636–4.029)

2.113E−05

1.881 (1.050–3.369)

3.363E− 02

PS model status (high/low)

216/216

3.287 (2.082–5.189)

4.096E−08

2.737 (1.447–5.178)

1.970E−03

Vital status (dead/alive)

96/336

–

–

–

–

Overall survival time (months, mean ± sd)

29.44 ± 25.43

–

–

–

–

  1. HR hazard ratio, CI confidential interval, TCGA The Cancer Genome Atlas, SD standard deviation