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Table 4 Univariate and Multivariable cox proportional hazards regression model for CSS in 2571 p-NET patients

From: Prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation

Characteristics

Univariate analysis

 

Multivariate analysis

 

Hazard ratio (95% CI)

P

Hazard ratio (95% CI)

P

Gender

 Male

1 (reference)

 

1 (reference)

 

 Female

0.746 (0.582-0.955)

0.020

0.745 (0.578-0.960)

0.023

Year of diagnosis

 200-2009

1 (reference)

 

1 (reference)

 

 2010-2017

0.411 (0.313-0.540)

 

0.640 (0.487-0.842)

0.001

Location of tumor

 Head of pancreas

1 (reference)

 

1 (reference)

 

 Body/tail of pancreas

0.609 (0.468-0.792)

0.000

0.624 (0.472-0.823)

0.001

 Othera

0.948 (0.648-1.388)

0.785

1.026 (0.690-1.525)

0.900

Type of tumor

 Functional

1 (reference)

   

 Non-functional

0.789 (0.556-1.119)

0.183

  

Histological grade

 G1

1 (reference)

 

1 (reference)

 

 G2

1.729 (1.264-2.367)

0.000

1.230 (0.893-1.693)

0.204

 G3

8.962 (6.707-11.975)

0.000

4.540 (3.337-6.177)

0.000

Distant metastasis

 No

1 (reference)

 

1 (reference)

 

 Yes

5.504 (4.308-7.032)

0.000

2.536 (1.899-3.387)

0.000

Tumor size

 ≤ 2 cm

1 (reference)

 

1 (reference)

 

 2-4 cm

3.199 (2.116-4.836)

0.000

1.646 (1.060-2.555)

0.026

 > 4 cm

4.895 (3.265-7.337)

0.000

1.711 (1.096-2.672)

0.018

AJCC 8th stage

 I-II

1 (reference)

 

1 (reference)

 

 III-IV

6.158 (4.200-9.029)

0.000

1.956 (1.167-3.278)

0.011

 Unknown

1.307 (0.682-2.505)

0.420

0.685 (0.298-1.572)

0.372

Lymph node

 Metastasis

1 (reference)

 

1 (reference)

 

 Yes

0.275 (0.206-0.366)

0.000

0.798 (0.551-1.131)

0.197

 No

0.508 (0.356-0.725)

0.000

1.769 (1.138-2.750)

0.011

 Not examinedb

    

Race

 White

1 (reference)

 

1 (reference)

 

 Black

0.938 (0.640-1.375)

0.742

1.132 (0.767-1.670)

0.533

 Otherc

0.554 (0.333-0.922)

0.023

0.573 (0.342-0.962)

0.035

Age at diagnosis (year)

 ≤ 60

1 (reference)

 

1 (reference)

 

 > 60

1.439 (1.123-1.844)

0.004

1.395 (1.081-1.801)

0.011

  1. Univariate analysis of variables with P < 0.1, then further analysis by multivariate Cox regression model
  2. aOverlapping lesion of the pancreas, pancreatic duct, and other specified parts of pancreas
  3. bNo lymph nodes were detected during surgery
  4. cAsian/American Indian/Alaska Native/Pacific Islander
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World Journal of Surgical Oncology

ISSN: 1477-7819

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