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Table 1 Indications and side effects of using monoclonal antibodies

From: Cessation of methotrexate and a small intestinal resection provide a good clinical course for a patient with a jejunum perforation induced by a methotrexate-associated lymphoproliferative disorder: a case report

Monoclonal antibody

Bevacizumab

Interleukin-2

Ipilimumab

Rituximab

Target

Vascular endothelial growth factor

Interleukin-2 receptor

Cytotoxic T lymphocyte antigen 4

CD20 antigen

Indications

Colorectal cancer, non-small cell lung cancer, and ovarian cancer

Melanoma and renal cell cancer

Melanoma and renal cell cancer

Hematologic B cell malignancies, nephrotic syndrome, and rheumatoid arthritis

Side effects

Hypertension, proteinuria, arterial thromboembolic events, wound healing complications, bleeding diathesis, and gastrointestinal perforations

Fever and chills, diarrhea, diffuse erythroderma, hyperbilirubinemia, anemia, thrombocytopenia, eosinophilia, a capillary leak syndrome, and intestinal perforation

Dermatitis, endocrinopathies, particularly hypophysitis, uveitis, nephritis, inflammatory myopathies, hepatitis, colitis, and intestinal perforation

Fever and chills, mucocutaneous reactions, fatal infusion reactions, progressive multifocal leukoencephalopathy, and intestinal perforation

  1. CD20 cluster of differentiation 20