Fig. 3

ALKBH2 knockdown inhibits cell migration and invasion of CRC cells via EMT signaling pathway. a Cell migration was assessed in Caco-2 and LOVO cells transfected with sh-ALKBH2 or sh-NC, **P < 0.01 vs. sh-NC. The number of migrated and invaded cells is significantly reduced in cells transfected with sh-ALKBH2 compared with the sh-NC group B. Transwell assay was performed to investigate cell invasion in Caco-2 and LOVO cells transfected with sh-ALKBH2 or sh-NC, **P < 0.01 vs. sh-NC. C. Expression changes in EMT-related signaling molecules in cells transfected with sh-ALKBH2 or sh-NC, **P < 0.01 vs. sh-NC. ALKBH2 knockdown increases E-cadherin expression and reduced N-cadherin level