Table 8 Association between polymorphisms of DPYD and GSTP1 genes and dermatology toxicity of chemotherapy
Genotype | Skin ulceration | Hand-foot skin reaction | |||||
|---|---|---|---|---|---|---|---|
Grade 1–2 | Grade 3–4 | P | Grade 1–2 | Grade 3–4 | P | ||
DPYD*5A (c.1627A>G) | WT | 2 | 1 | Ref. | 5 | 1 | Ref. |
HET | 2 | 1 | 1.000 | 4 | 3 | 0.308 | |
HOM | 2 | 2 | 0.659 | 2 | 1 | 0.571 | |
HET + HOM | 4 | 3 | 0.778 | 6 | 4 | 0330 | |
DPYD*9A (c.85T>C) | WT | 6 | 4 | Ref. | 10 | 5 | Ref. |
HET | 0 | 0 | – | 1 | 0 | 0.486 | |
HOM | 0 | 0 | – | 0 | 0 | – | |
HET + HOM | 0 | 0 | – | 1 | 0 | 0.486 | |
GSTP1 (c.313A>G) | WT | 5 | 1 | Ref. | 8 | 2 | Ref. |
HET | 0 | 3 | 0.018 | 3 | 3 | 0.210 | |
HOM | 0 | 0 | – | 0 | 0 | – | |
HET + HOM | 0 | 3 | 0.018 | 3 | 3 | 0.210 | |