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Table 6 Association between polymorphisms of DPYD and GSTP1 genes and hematological toxicity of chemotherapy

From: Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms

Genotype

Anemia

Neutropenia

Thrombocytopenia

Leucopenia

Grade 1–2

Grade 3–4

P

Grade 1–2

Grade 3–4

P

Grade 1–2

Grade 3–4

P

Grade 1–2

Grade 3–4

P

DPYD*5A (c.1627A > G)

WT

29

11

Ref.

22

8

Ref.

23

6

Ref.

28

6

Ref.

HET

16

7

0.804

14

7

0.607

14

5

0.650

17

4

0.896

HOM

1

1

0.492

3

1

0.943

2

1

0.614

3

0

0.427

HET + HOM

17

8

0.698

17

8

0.665

16

6

0.583

20

4

0.922

DPYD*9A (c.85T>C)

WT

34

15

Ref.

31

10

Ref.

27

8

Ref.

37

7

Ref.

HET

12

4

0.668

8

6

0.189

12

4

0.867

11

3

0.794

HOM

0

0

–

0

0

–

0

0

–

0

0

–

HET + HOM

12

4

0.668

8

6

0.189

12

4

0.867

11

3

0.794

GSTP1 (c.313A>G)

WT

31

14

Ref.

30

13

Ref.

26

8

Ref.

35

7

Ref.

HET

14

4

0.480

9

3

0.724

11

3

0.875

11

2

0.913

HOM

1

1

0.575

0

0

–

1

1

0.401

2

1

0.466

HET + HOM

15

5

0.617

9

3

0.724

12

4

0.910

13

3

0.851