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Table 4 Associations between relapse-free survival proportions and clinical factors demonstrated by univariable and multivariable analyses

From: Is left-sided involvement of hepatocellular carcinoma an important preoperative predictive factor of poor outcome?

  

Univariable analysis

Multivariable analysis (only preoperative factors)

HR

95% CI

p value

HR

95% CI

p valuea

Age

Continuous

1.016

1.012–1.034

0.36

1.011

1.005–1.017

0.062

Sex

Female

Ref

    

Ref

    
 

Male

0.892

0.542–1.076

0.407

1.324

1.197–1.451

0.028

Location

RGS

Ref

    

Ref

    
 

LGS

1.269

1.029–1.565

0.026

1.208

1.104–1.312

0.048

Resection type

Anatomical resection

Ref

         
 

Non-anatomical resection

1.372

1.024–1.838

0.022

–

–

–

–

–

ICGR

Continuous

1.021

1.018–1.032

< 0.001

1.011

0.007–1.022

0.019

AFP, ng/mL

< 13

Ref

    

Ref

    
 

> 13.1

1.631

1.416–1.879

< 0.001

1.555

1.114–1.654

< 0.001

PIVKA2, ng/mL

< 40

Ref

    

Ref

    
 

> 41

1.475

1.28–1.699

< 0.001

1.252

1.146–1.358

0.035

Tumor size, cm

< 5

Ref

    

Ref

    
 

> 5.1

2.221

1.745–2.783

< 0.001

1.897

1.773–2.021

< 0.001

Operative time, min

< 270

Ref

 

–

       
 

> 271

1.558

1.354–1.792

< 0.001

–

–

–

–

–

Blood loss, ml

< 300

Ref

 

–

       
 

> 301

1.429

1.233–1.657

< 0.001

–

–

–

–

–

HBV

Negative

Ref

 

–

  

Ref

    
 

Positive

1.431

1.224–1.672

< 0.001

0.821

0.656–0.986

0.231

HCV

Negative

Ref

 

–

       
 

Positive

1.155

0.997–1.351

0.055

–

–

–

–

–

Hepatic vein invasion

Negative

Ref

 

–

       
 

Positive

1.902

1.264–2.861

< 0.001

–

–

–

–

–

Portal vein invasion

Negative

Ref

 

–

       
 

Positive

1.456

1.231–1.724

< 0.001

–

–

–

–

–

  1. HR hazard ratios, 95%CI 95% confidence interval
  2. aInput criteria for multiple analysis were preoperative factors with p < 0.05 in univariate analysis with age and sex