Table 1 The clinicopathological characteristics of the cHCC-CCA, HCC, and iCCA cases. HBsAg hepatitis B surface antigen, HCV-Ab hepatitis C virus antibody, AFP alpha-fetoprotein, DCP des-gamma-carboxy prothrombin, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, AR anatomical resection, NAR non-anatomical resection, NS not significant. Numbers are described as the mean ± standard deviation. Values in parentheses are percentages

Sex

Male: 12

Female: 7

Male: 583

Female: 159

Male: 72

Female: 49

p < 0.0001

Age

64.1 ± 10.6

66.7 ± 9.7

66.7 ± 10.0

NS

Platelet number (× 10⁴/μL)

17.2 ± 10.7

13.6 ± 7.8

19.1 ± 9.0

HCC vs. iCCA: p < 0.0001

Total bilirubin (mg/dL)

1.19 ± 0.71

1.05 ± 1.21

0.89 ± 0.72

NS

Albumin (g/dL)

3.91 ± 0.50

3.82 ± 0.54

3.99 ± 0.47

HCC vs. iCCA: p = 0.0032

Prothrombin time (%)

83.6 ± 12.0

83.7 ± 15.7

91.6 ± 16.0

HCC vs. iCCA: p < 0.0001

HBsAg

Positive: 3 (15.8%)

Negative: 16 (84.2%)

Missing data: 0

Positive: 147 (19.8%)

Negative: 588 (79.2%)

Missing data: 7

Positive: 7 (5.8%)

Negative: 109 (90.1%)

Missing data: 5

p < 0.0001

HCV-Ab

Positive: 8 (42.1%)

Negative: 11 (57.9%)

Missing data: 0

Positive: 336 (45.3%)

Negative: 400 (53.9%)

Missing data: 6

Positive: 16 (13.2%)

Negative: 102 (84.3%)

Missing data: 3

p < 0.0001

AFP (ng/mL)

110.7 ± 343.5

7416 ± 108118.1

12.6 ± 49.3

NS

DCP (mAU/mL)

1613.3 ± 5099.2

7895.5 ± 35673.2

693.1 ± 3890.6

NS

CEA (ng/mL)

2.88 ± 3.01

3.65 ± 2.61

7.36 ± 18.9

HCC vs. iCCA: p = 0.0015

CA19-9 (U/mL)

37.2 ± 31.6

48.3 ± 55.1

308.7 ± 760.4

HCC vs. iCCA: p < 0.0001

cHCC-CCA vs. iCCA: p = 0.0294

Tumor number

1.21 ± 0.42

1.68 ± 1.56

1.48 ± 1.70

NS

Tumor size (cm)

4.07 ± 2.39

4.68 ± 4.19

4.63 ± 2.75

NS

Major portal vein invasion

Presence: 3 (15.8%)

Absence: 16 (84.2%)

Missing data: 0

Presence: 67 (9.0%)

Absence: 618 (83.3%)

Missing data: 57

Presence: 14 (11.6%)

Absence: 94 (77.7%)

Missing data: 13

NS

Major hepatic vein invasion

Presence: 0 (0%)

Absence: 19 (100%)

Missing data: 0

Presence: 25 (3.4%)

Absence: 658 (88.7%)

Missing data: 59

Presence: 9 (7.4%)

Absence: 99 (81.8%)

Missing data: 13

NS

Major biliary tract invasion

Presence: 7 (36.8%)

Absence: 12 (63.2%)

Missing data: 0

Presence: 37 (5.0%)

Absence: 646 (87.1%)

Missing data: 59

Presence: 22 (18.2%)

Absence: 80 (66.1%)

Missing data: 19

p < 0.0001

Surgical procedure

AR: 13 (68.4%)

NAR: 6 (31.6%)

AR: 471 (63.5%)

NAR: 271 (36.5%)

AR: 95 (78.5%)

NAR: 26 (21.5%)

p = 0.0053

Resection of extrahepatic bile duct

Presence: 1 (5.3%)

Absence: 18 (94.7%)

Presence: 3 (0.4%)

Absence: 739 (99.6%)

Presence: 29 (24.0%)

Absence: 92 (76.0%)

p < 0.0001

Lymph node dissection

Presence: 1 (5.3%)

Absence: 18 (94.7%)

Presence: 9 (1.2%)

Absence: 733 (98.8%)

Presence: 93 (76.9%)

Absence: 28 (23.1%)

p < 0.0001