Time 1 | Time 2 | Time 3 | Time 4 | Time 5 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
H | L | P | H | L | P | H | L | P | H | L | P | H | L | P | |
QLQ C-30 | |||||||||||||||
Physical | 90.3 | 97.6 | 0.001 | 87.5 | 97.2 | 0.001 | 67.6 | 91.3 | < 0.001 | 67.6 | 90.0 | < 0.001 | 76.7 | 95.2 | < 0.001 |
Role | 84.6 | 95.0 | 0.017 | 75.8 | 88.9 | 0.011 | 47.6 | 87.7 | < 0.001 | 43.3 | 86.7 | < 0.001 | 58.3 | 92.8 | < 0.001 |
Emotional | 63.9 | 90.6 | < 0.001 | 64.3 | 92.0 | < 0.001 | 62.5 | 96.0 | < 0.001 | 65.3 | 95.7 | < 0.001 | 64.3 | 97.9 | < 0.001 |
Cognitive | 73.6 | 93.8 | < 0.001 | 74.4 | 93.4 | < 0.001 | 57.8 | 94.1 | < 0.001 | 59.1 | 91.7 | < 0.001 | 66.7 | 92.8 | < 0.001 |
Social | 66.7 | 90.0 | 0.001 | 70.0 | 82.5 | 0.045 | 56.9 | 88.5 | < 0.001 | 42.6 | 92.6 | < 0.001 | 56.7 | 94.8 | < 0.001 |
Global health | 41.7 | 80.1 | < 0.001 | 50.0 | 76.8 | 0.002 | 35.7 | 72.7 | < 0.001 | 39.8 | 67.7 | < 0.001 | 40.5 | 78.3 | < 0.001 |
Fatigue | 33.3 | 14.2 | 0.001 | 33.3 | 14.2 | < 0.001 | 44.4 | 26.9 | < 0.001 | 55.6 | 31.0 | < 0.001 | 57.4 | 24.7 | < 0.001 |
Nausea | 8.8 | 2.4 | 0.014 | 9.4 | 1.9 | 0.006 | 7.4 | 2.4 | 0.040 | 13.9 | 6.5 | 0.132 | 20.8 | 4.9 | 0.005 |
Pain | 16.7 | 3.8 | 0.003 | 11.9 | 3.4 | 0.017 | 40.9 | 16.7 | < 0.001 | 29.5 | 6.8 | < 0.001 | 27.1 | 3.1 | < 0.001 |
Dyspnea | 15.9 | 9.9 | 0.187 | 13.3 | 9.3 | 0.383 | 38.1 | 17.2 | 0.003 | 42.2 | 22.6 | 0.017 | 48.5 | 17.2 | < 0.001 |
Insomnia | 20.4 | 12.0 | 0.182 | 24.1 | 12.0 | 0.034 | 51.9 | 24.0 | 0.001 | 37.0 | 14.0 | < 0.001 | 25.6 | 6.7 | 0.002 |
Appetite loss | 25.5 | 7.4 | 0.002 | 25.0 | 7.6 | 0.003 | 43.7 | 13.5 | 0.001 | 52.4 | 20.2 | 0.001 | 43.3 | 23.5 | 0.032 |
Constipation | 14.0 | 6.9 | 0.149 | 20.4 | 11.5 | 0.140 | 18.5 | 11.1 | 0.212 | 7.0 | 10.8 | 0.418 | 16.7 | 6.5 | 0.047 |
Diarrhea | 14.0 | 7.9 | 0.182 | 17.5 | 7.4 | 0.031 | 41.2 | 33.3 | 0.389 | 45.2 | 22.6 | 0.015 | 43.6 | 17.3 | 0.002 |
Financial | 48.3 | 13.0 | < 0.001 | 41.2 | 13.3 | < 0.001 | 40.5 | 12.5 | 0.001 | 44.4 | 7.3 | < 0.001 | 30.3 | 8.9 | 0.003 |
OES 18 | |||||||||||||||
Dysphagia | 63.5 | 94.8 | 0.003 | 82.2 | 96.1 | 0.002 | 62.5 | 92.6 | < 0.001 | 64.4 | 84.8 | < 0.001 | 63.5 | 89.9 | 0.328 |
Eating | 58.3 | 93.5 | < 0.001 | 68.3 | 94.3 | 0.001 | 59.3 | 83.9 | < 0.001 | 41.7 | 74.3 | < 0.001 | 47.2 | 78.8 | 0.010 |
Reflux | 87.5 | 96.2 | 0.004 | 87.8 | 96.2 | 0.010 | 86.1 | 94.6 | 0.040 | 81.7 | 90.0 | 0.122 | 75.9 | 91.0 | 0.161 |
Eso. pain | 82.7 | 98.0 | < 0.001 | 87.5 | 97.4 | 0.005 | 71.4 | 93.8 | 0.001 | 75.9 | 94.0 | 0.005 | 74.1 | 97.5 | 0.010 |
Saliva | 90.0 | 97.4 | 0.033 | 90.5 | 100 | 0.026 | 80.4 | 95.4 | 0.002 | 74.5 | 91.7 | 0.002 | 91.1 | 96.8 | 0.442 |
Choking | 86.7 | 96.5 | 0.011 | 88.3 | 97.4 | 0.012 | 74.5 | 90.7 | 0.003 | 70.6 | 88.9 | 0.001 | 73.8 | 89.2 | 0.105 |
Dry mouth | 70.8 | 88.0 | 0.009 | 70.8 | 85.2 | 0.031 | 58.8 | 79.3 | 0.007 | 57.1 | 86.0 | 0.002 | 69.7 | 92.5 | 0.442 |
Taste | 87.0 | 95.4 | 0.073 | 76.2 | 91.7 | 0.050 | 66.7 | 88.6 | < 0.001 | 61.5 | 89.6 | 0.001 | 69.4 | 89.7 | 0.161 |
Cough | 90.0 | 94.6 | 0.249 | 86.0 | 94.6 | 0.053 | 64.1 | 78.1 | 0.092 | 53.3 | 79.0 | 0.009 | 60.6 | 85.1 | 0.721 |
Speech | 91.7 | 94.4 | 0.469 | 95.0 | 94.4 | 0.899 | 62.2 | 81.2 | 0.010 | 47.6 | 72.6 | 0.004 | 56.7 | 92.2 | 0.721 |