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Table 3 The association between NLNs and CSS together with OS in univariate and multivariate analyses with PSM

From: Association between number of dissected lymph nodes and survival in stage IA non-small cell lung cancer: a propensity score matching analysis

  

CSS

OS

Variable

Number

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

p value

HR (95%CIs)

p value

p value

HR (95%CIs)

p value

NLNs

 ≤ 5

2350

 

1 (reference)

  

1 (reference)

 

 > 5

2350

< 0.001

0.631 (0.557–0.714)

< 0.001

< 0.001

0.650 (0.597–0.708)

< 0.001

Sex

 Male

1908

 

1 (reference)

  

1 (reference)

 

 Female

2790

< 0.001

0.631 (0.557–0.714)

< 0.001

< 0.001

0.714 (0.657–0.777)

< 0.001

Age

 ≤ 65

1975

 

1 (reference)

  

1 (reference)

 

 > 65

2725

< 0.001

1.410 (1.244–1.599)

< 0.001

< 0.001

1.829 (1.671–2.002)

< 0.001

TNM stage

 IA1

699

 

1 (reference)

  

1 (reference)

 

 IA2

4001

0.005

1.153 (0.900–1.478)

0.261

0.003

1.117 (0.944–1.322)

0.197

Grade

 I

1055

 

1 (reference)

  

1 (reference)

 

 II

2044

< 0.001

2.094 (1.724–2.543)

< 0.001

< 0.001

1.642 (1.446–1.864)

< 0.001

 III

1187

< 0.001

2.762 (2.242–3.402)

< 0.001

< 0.001

2.055 (1.791–2.360)

< 0.001

 IV

64

0.007

1.574 (0.901–2.748)

0.111

0.007

1.248 (0.843–1.847)

0.268

 Unknown

350

0.005

1.643 (1.222–2.210)

0.001

0.037

1.277 (1.045–1.560)

0.017

Tumor location (%)

 Upper lobe

2783

      

 Middle lobe

294

0.640

  

0.158

  

 Lower lobe

1560

0.627

  

0.443

  

 Main bronchus

2

0.982

  

0.973

  

 Overlapping

20

0.891

  

0.977

  

 Lung NOS

41

0.079

  

0.230

  

Tumor size (mm)

–

< 0.001

1.019 (0.997–1.042)

0.094

< 0.001

1.014 (0.999–1.030)

0.066

Race

 American Indian

22

      

 Asian

289

0.820

  

0.225

  

 Black

393

0.455

  

0.865

  

 White

3989

0.667

  

0.924

  

 Unknown

7

0.978

  

0.967

  

Surgical methods

 Wedge resection

460

 

1 (reference)

  

1 (reference)

 

 Segmental resection

158

0.025

0.546 (0.392–0.761)

< 0.001

< 0.001

0.503 (0.396–0.638)

< 0.001

 Lobectomy

4060

< 0.001

0.339 (0.283–0.405)

< 0.001

< 0.001

0.353 (0.312–0.400)

< 0.001

 Pneumonectomy

22

0.533

0.581 (0.256–1.318)

0.194

0.225

0.537 (0.301–0.958)

0.035

 Unknown

0

NA

NA

NA

   

Histological types

 Adeno

3157

 

1 (reference)

  

1 (reference)

 

 SCC

1004

< 0.001

1.064 (0.915–1.237)

0.424

< 0.001

1.371 (1.240–1.516)

< 0.001

 LCC

116

< 0.001

1.640 (1.163–2.314

0.005

< 0.001

1.585 (1.228–2.045)

< 0.001

 PSC

1

0.981

0.000 (0.000–Inf)

0.981

0.981

0.000 (0.000–Inf)

0.972

 Other

270

0.140

1.140 (0.883–1.472)

0.314

0.082

1.117 (0.929–1.342)

0.240

 Unknown

152

0.575

0.867 (0.612–1.228)

0.422

0.008

1.086 (0.867–1.361)

0.472

  1. NSCLC non-small cell lung cancer, NLNs the number of removed lymph nodes, PSM propensity score matching, HR hazard ratio, CIs confident intervals, Lung NOS uncertain location on lung, Adeno adenocarcinoma, SCC squamous cell carcinoma, LCC large cell carcinoma, PSC pulmonary sarcomatoid carcinoma, Other other histological types, Inf infinity
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World Journal of Surgical Oncology

ISSN: 1477-7819

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