Fig. 1

Characteristics of variants identified in the BLCA study cohort. a Cumulative frequencies of variants in individual BLCA cases. b Oncoplot displaying the somatic landscape of the BLCA cohort. Genes are ordered by their mutation frequency. The side bar plot displays Q values estimated by MutSigCV. c Bundled bar chart classifying variant types using the variant effect predictor (VEP). d Stacked bar chart summarizing the variant types of all cases with substitutions, insertions, and deletions. e Histogram showing the cumulative frequency of variants for individual cases. The median of mutation number per sample is 148. f Statistical analysis of differences among different variant types (Wilcoxon rank-sum test, p < 0.0001)