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Table 2 Univariate and multivariate analyses of prognostic features and overall survival

From: PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome

  OS
Variable Univariate analysis Multivariate analyses
HR (95%CI) P HR (95%CI) P
Age (years)
 <60 vs. ≥ 60 1.014 (0.770–1.335) 0.920   
Gender
 Male vs. female 1.144 (0.863–1.519) 0.350   
HBsAg
 Negative vs. positive 0.786 (0.590–1.046) 0.099   
Cirrhosis
 No vs. yes 1.195 (0.883–1.617) 0.249   
CA19-9
 Low (≤ 37) vs. high (> 37) 1.564 (1.188–2.059) 0.001   
Child-Pugh
 A vs.B 0.879 (0.390–1.981) 0.756   
Size (cm)
 ≤ 5 vs. > 5 1.521 (1.149–2.013) 0.003   
Number
 Single vs. multiple 1.626 (1.196–2.209) 0.002   
LN invasion
 No vs. yes 2.752 (1.984–3.818) 0.000   
TNM stage
 I vs. II–III 2.310 (1.711–3.120) 0.000   
MVI
 No vs. yes 1.196 (0.816–1.752) 0.360   
PD-1
 Low vs. high 0.431 (0.320–0.580) 0.000 0.457 (0.337–0.619) 0.000a
PD-L1
 Low vs. high 1.332 (0.982–1.806) 0.650 NA NA
CD8
 Low vs. high 0.615 (0.462–0.819) 0.001 0.629 (0.470–0.842) 0.002b
CD68
 Low vs. high 0.795 (0.599–1.055) 0.112 NA NA
CD8PD1High/CD8PD1
 Low vs. high 1.736 (1.184–2.547) 0.005 1.557 (1.057–2.292) 0.025c
CD8PD1Low/CD8PD1
 Low vs. high 0.576 (0.393–0.845) 0.005 0.642 (0.436–0.946) 0.025d
CD68PDL1/CD68
 Low vs. high 1.388 (1.022–1.884) 0.036 1.111 (0.809–1.527) 0.514e
  1. Cox regression model was performed
  2. HBsAg hepatitis B surface antigen, CA19-9 carbohydrate antigen 19-9, LN lymph node, TNM tumor-nodes-metastasis, MVI microvascular invasion
  3. a, b, c, d, and e CA19-9, size, number, LN invasion, and TNM stage were adjusted in multivariate analysis