From: PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome
 | OS | |||
---|---|---|---|---|
Variable | Univariate analysis | Multivariate analyses | ||
HR (95%CI) | P | HR (95%CI) | P | |
Age (years) | ||||
 <60 vs. ≥ 60 | 1.014 (0.770–1.335) | 0.920 |  |  |
Gender | ||||
 Male vs. female | 1.144 (0.863–1.519) | 0.350 |  |  |
HBsAg | ||||
 Negative vs. positive | 0.786 (0.590–1.046) | 0.099 |  |  |
Cirrhosis | ||||
 No vs. yes | 1.195 (0.883–1.617) | 0.249 |  |  |
CA19-9 | ||||
 Low (≤ 37) vs. high (> 37) | 1.564 (1.188–2.059) | 0.001 |  |  |
Child-Pugh | ||||
 A vs.B | 0.879 (0.390–1.981) | 0.756 |  |  |
Size (cm) | ||||
 ≤ 5 vs. > 5 | 1.521 (1.149–2.013) | 0.003 |  |  |
Number | ||||
 Single vs. multiple | 1.626 (1.196–2.209) | 0.002 |  |  |
LN invasion | ||||
 No vs. yes | 2.752 (1.984–3.818) | 0.000 |  |  |
TNM stage | ||||
 I vs. II–III | 2.310 (1.711–3.120) | 0.000 |  |  |
MVI | ||||
 No vs. yes | 1.196 (0.816–1.752) | 0.360 |  |  |
PD-1 | ||||
 Low vs. high | 0.431 (0.320–0.580) | 0.000 | 0.457 (0.337–0.619) | 0.000a |
PD-L1 | ||||
 Low vs. high | 1.332 (0.982–1.806) | 0.650 | NA | NA |
CD8 | ||||
 Low vs. high | 0.615 (0.462–0.819) | 0.001 | 0.629 (0.470–0.842) | 0.002b |
CD68 | ||||
 Low vs. high | 0.795 (0.599–1.055) | 0.112 | NA | NA |
CD8PD1High/CD8PD1 | ||||
 Low vs. high | 1.736 (1.184–2.547) | 0.005 | 1.557 (1.057–2.292) | 0.025c |
CD8PD1Low/CD8PD1 | ||||
 Low vs. high | 0.576 (0.393–0.845) | 0.005 | 0.642 (0.436–0.946) | 0.025d |
CD68PDL1/CD68 | ||||
 Low vs. high | 1.388 (1.022–1.884) | 0.036 | 1.111 (0.809–1.527) | 0.514e |