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Table 2 Univariate and multivariate analyses of prognostic features and overall survival

From: PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome

 

OS

Variable

Univariate analysis

Multivariate analyses

HR (95%CI)

P

HR (95%CI)

P

Age (years)

 <60 vs. ≥ 60

1.014 (0.770–1.335)

0.920

  

Gender

 Male vs. female

1.144 (0.863–1.519)

0.350

  

HBsAg

 Negative vs. positive

0.786 (0.590–1.046)

0.099

  

Cirrhosis

 No vs. yes

1.195 (0.883–1.617)

0.249

  

CA19-9

 Low (≤ 37) vs. high (> 37)

1.564 (1.188–2.059)

0.001

  

Child-Pugh

 A vs.B

0.879 (0.390–1.981)

0.756

  

Size (cm)

 ≤ 5 vs. > 5

1.521 (1.149–2.013)

0.003

  

Number

 Single vs. multiple

1.626 (1.196–2.209)

0.002

  

LN invasion

 No vs. yes

2.752 (1.984–3.818)

0.000

  

TNM stage

 I vs. II–III

2.310 (1.711–3.120)

0.000

  

MVI

 No vs. yes

1.196 (0.816–1.752)

0.360

  

PD-1

 Low vs. high

0.431 (0.320–0.580)

0.000

0.457 (0.337–0.619)

0.000a

PD-L1

 Low vs. high

1.332 (0.982–1.806)

0.650

NA

NA

CD8

 Low vs. high

0.615 (0.462–0.819)

0.001

0.629 (0.470–0.842)

0.002b

CD68

 Low vs. high

0.795 (0.599–1.055)

0.112

NA

NA

CD8PD1High/CD8PD1

 Low vs. high

1.736 (1.184–2.547)

0.005

1.557 (1.057–2.292)

0.025c

CD8PD1Low/CD8PD1

 Low vs. high

0.576 (0.393–0.845)

0.005

0.642 (0.436–0.946)

0.025d

CD68PDL1/CD68

 Low vs. high

1.388 (1.022–1.884)

0.036

1.111 (0.809–1.527)

0.514e

  1. Cox regression model was performed
  2. HBsAg hepatitis B surface antigen, CA19-9 carbohydrate antigen 19-9, LN lymph node, TNM tumor-nodes-metastasis, MVI microvascular invasion
  3. a, b, c, d, and e CA19-9, size, number, LN invasion, and TNM stage were adjusted in multivariate analysis