Skip to main content

Table 1 Correlation between the expression of PD-1, PD-L1, CD8, and CD68 and clinicopathological features

From: PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome

Characteristics PD-1+ PD-L1+ CD8+ CD68+
Low High P Low High P Low High P Low High P
Age, years
 < 60 41 132 0.965 124 49 0.120 54 119 0.646 100 73 0.551
 ≥ 60 35 114 118 31 43 106 91 58
Gender
 Female 36 92 0.121 110 18 0.000 49 79 0.010 87 41 0.010
 Male 40 154 132 62 48 146 104 90
HBsAg
 Negative 55 144 0.030 153 46 0.361 67 132 0.078 125 74 0.104
 Positive 21 102 89 34 30 93 66 57
Cirrhosis
 No 58 178 0.495 181 55 0.290 72 164 0.803 142 94 0.606
 Yes 18 68 61 25 25 61 49 37
CA19-9
 Low (≤ 37) 28 135 0.006 128 35 0.156 39 124 0.014 96 67 0.876
 High (> 37) 48 111 114 45 58 101 95 64
Child-Pugh
 A 75 236 0.250 236 75 0.107 97 214 0.027 185 126 0.743
 B 1 10 6 5 0 11 6 5
Tumor size (cm)
 ≤ 5 25 120 0.015 107 38 0.609 33 112 0.009 73 72 0.003
 > 5 51 126 135 42 64 113 118 59
Tumor number
 Single 57 187 0.857 188 56 0.164 72 172 0.670 154 90 0.014
 Multiple 19 59 54 24 25 53 37 41
LN invasion
 No 61 205 0.537 208 58 0.006 81 185 0.781 157 109 0.815
 Yes 15 41 34 22 16 40 34 22
TNM stage
 I 55 192 0.306 193 54 0.025 74 173 0.907 144 103 0.500
 II–III 21 54 49 26 23 52 47 28
MVI
 No 63 213 0.422 208 68 0.833 83 193 0.960 164 112 0.926
 Yes 13 33 34 12 14 32 27 19
  1. Chi-square test and Fisher’s exact test were performed
  2. HBsAg hepatitis B surface antigen, CA19-9 carbohydrate antigen 19-9, LN lymph node, TNM tumor-nodes-metastasis, MVI microvascular invasion