PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome

Table 1 Correlation between the expression of PD-1, PD-L1, CD8, and CD68 and clinicopathological features

Characteristics	PD-1⁺			PD-L1⁺			CD8⁺			CD68⁺
Characteristics	Low	High	P	Low	High	P	Low	High	P	Low	High	P
Age, years
< 60	41	132	0.965	124	49	0.120	54	119	0.646	100	73	0.551
≥ 60	35	114	0.965	118	31	0.120	43	106	0.646	91	58	0.551
Gender
Female	36	92	0.121	110	18	0.000	49	79	0.010	87	41	0.010
Male	40	154	0.121	132	62	0.000	48	146	0.010	104	90	0.010
HBsAg
Negative	55	144	0.030	153	46	0.361	67	132	0.078	125	74	0.104
Positive	21	102	0.030	89	34	0.361	30	93	0.078	66	57	0.104
Cirrhosis
No	58	178	0.495	181	55	0.290	72	164	0.803	142	94	0.606
Yes	18	68	0.495	61	25	0.290	25	61	0.803	49	37	0.606
CA19-9
Low (≤ 37)	28	135	0.006	128	35	0.156	39	124	0.014	96	67	0.876
High (> 37)	48	111	0.006	114	45	0.156	58	101	0.014	95	64	0.876
Child-Pugh
A	75	236	0.250	236	75	0.107	97	214	0.027	185	126	0.743
B	1	10	0.250	6	5	0.107	0	11	0.027	6	5	0.743
Tumor size (cm)
≤ 5	25	120	0.015	107	38	0.609	33	112	0.009	73	72	0.003
> 5	51	126	0.015	135	42	0.609	64	113	0.009	118	59	0.003
Tumor number
Single	57	187	0.857	188	56	0.164	72	172	0.670	154	90	0.014
Multiple	19	59	0.857	54	24	0.164	25	53	0.670	37	41	0.014
LN invasion
No	61	205	0.537	208	58	0.006	81	185	0.781	157	109	0.815
Yes	15	41	0.537	34	22	0.006	16	40	0.781	34	22	0.815
TNM stage
I	55	192	0.306	193	54	0.025	74	173	0.907	144	103	0.500
II–III	21	54	0.306	49	26	0.025	23	52	0.907	47	28	0.500
MVI
No	63	213	0.422	208	68	0.833	83	193	0.960	164	112	0.926
Yes	13	33	0.422	34	12	0.833	14	32	0.960	27	19	0.926

Chi-square test and Fisher’s exact test were performed
HBsAg hepatitis B surface antigen, CA19-9 carbohydrate antigen 19-9, LN lymph node, TNM tumor-nodes-metastasis, MVI microvascular invasion

ISSN: 1477-7819