Fig. 4
From: PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome
Different expression patterns of PD-L1 in CD68+ macrophages in ICC tumors and prognostic implication in ICC patients. a Representative multiplex immunofluorescence staining with the indicated immune markers of CD68+ PD-L1+ in ICC tumor and peri-tumor tissues. Scale bar, 50 μm. b Quantitative comparisons analysis of the proportion of CD68+ PD-L1+ between paired tumor tissues (T) and peri-tumor tissues (P) in the ICC patients (Wilcoxon signed-rank test). c Kaplan-Meier analysis of overall survival (OS) and relapse-free survival (RFS) in ICC according to the frequency of CD68+ PD-L1 within CD68+ PD-1+