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Table 3 Results of meta-analysis comparing TME + LLND versus TME alone

From: Lateral lymph node dissection reduces local recurrence of locally advanced lower rectal cancer in the absence of preoperative neoadjuvant chemoradiotherapy: a systematic review and meta-analysis

  Number of studies TME + LLND patients TME patients Total patients HR/RR/WMD (95% CI) P value Study heterogeneity
        χ2 df I2 P value
Survival
 5-year survival 4 1088 1101 2189 0.93a(0.71–1.22) 0.62 6 3 50% 0.11
 5-year disease-free survival 5 868 684 1552 0.99a(0.74–1.34) 0.96 9.93 5 50% 0.08
Recurrence
 Total recurrence 4 653 454 1107 0.98(0.81–1.18) 0.83 2.37 4 0% 0.67
 Local recurrence 7 1290 1930 3220 0.71(0.56–0.89) 0.003 9.22 7 24% 0.24
 Lateral recurrence 3 773 1596 2369 0.49(0.18–1.28) 0.14 5.87 2 66% 0.05
 Distant recurrence 5 615 1204 1819 0.95(0.68–1.34) 0.78 8.84 5 43% 0.12
Peri-operative outcomes
 Length of operation (min) 4 716 479 1195 97.03b(75.35–118.72) P < 0.001 82.14 3 96% P < 0.001
 Blood loss (mL) 4 716 479 1195 303.20b(156.82–449.58) P < 0.001 201.99 3 99% P < 0.001
 Peri-operative mortality 2 578 414 992 1.52(0.18–12.65) 0.7 0.47 1 0% 0.49
 Postoperative complications 3 578 414 992 1.35(1.05–1.74) 0.02 0.53 2 0% 0.77
Functional outcomes           
 Urinary dysfunction 2 374 372 746 1.44(0·63–3.28) 0·38 4.93 1 80% 0.03
 Sexual dysfunction 2 108 92 200 1.41(0.87–2.31) 0·17 2.23 1 55% 0.13
  1. HR hazard ratio, RR risk ratio, WMD weighted mean difference, df degrees of freedom
  2. aHR
  3. bWMD