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Fig. 5 | World Journal of Surgical Oncology

Fig. 5

From: Membranous S100A10 involvement in the tumor budding of colorectal cancer during oncogenesis: report of two cases with immunohistochemical analysis

Fig. 5

Routine pathological findings of the colon cancer in case 2. a Gross view shows a circumferential ulcerated tumor (surrounded by arrowheads). Scale bar: 1 cm. b The tumor invades the subserosa (arrows). The tumor consists mainly of an adenocarcinoma with a tubular growth pattern, but many of the cell clusters with lacunar space are distributed in the invasion front and inside the tumor (arrowheads). Hematoxylin and eosin (H&E) stain. Scale bar: 2 mm. c The cell clusters with lacunar space are scattered around the tumor glands, and many of them consist of more than five tumor cells, regarded as PDCs (arrowheads). H&E stain. Scale bar: 200 μm. d In the tumor glands giving rise to PDCs, the shape appears more irregular, protruding into the stroma in a cord-like or small nest appearance (arrows). Arrowheads indicate PDC. H&E stain. Scale bar: 100 μm

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