Variables | n (%) | 5-year survival rate (%) | P | HR (95% CI) | P | Non-GBAI (%) | GBAI | P | HR (95% CI) | P |
---|---|---|---|---|---|---|---|---|---|---|
Gender | ||||||||||
Female | 602 (33.0) | 60.0 | 0.580 | 534 (33.0) | 68 (33.2) | 0.883 | ||||
Male | 1220 (67.0) | 61.3 | 1083 (67.0) | 137 (66.8) | ||||||
Age (years) | ||||||||||
< 50 | 478 (26.2) | 66.3 | 0.004 | ref. | 432 (26.7) | 46 (22.4) | 0.176 | |||
≥ 50 | 1244 (73.8) | 58.9 | 1.02 (1.01–1.03) | < 0.001 | 1185 (73.3) | 159 (77.6) | ||||
Tumor size (cm) | ||||||||||
≤ 5.0 | 1210 (66.4) | 66.5 | < 0.001 | ref. | 1112 (68.8) | 98 (47.8) | < 0.001 | ref. | ||
> 5.0 | 612 (33.6) | 49.7 | 1.03 (0.89–1.20) | 0.668 | 505 (31.2) | 107 (52.2) | 1.08 (0.87–1.33) | 0.304 | ||
Tumor site | ||||||||||
Distal | 1006 (55.2) | 70.3 | < 0.001 | ref. | 954 (59.0) | 52 (25.4) | < 0.001 | ref. | ||
Proximal/linitis lastica | 816 (44.8) | 49.3 | 1.43 (1.23–1.68) | < 0.001 | 663 (41.0) | 153 (74.6) | 1.63 (1.40–1.90) | < 0.001 | ||
Histological grade | ||||||||||
Well/moderately differentiated | 262 (14.4) | 69.5 | 0.234 | 247 (15.3) | 15 (7.3) | 0.009 | ref. | |||
Poorly differentiated | 1197 (65.7) | 58.3 | 1054 (65.2) | 143 (69.8) | 1.18 (0.93–1.51) | 0.174 | ||||
Undifferentiated/signet ring cell carcinoma | 363 (19.9) | 63.1 | 316 (19.5) | 47 (22.9) | 1.16 (0.87–1.54) | 0.309 | ||||
Vascular invasion | ||||||||||
No | 1529 (83.9) | 62.9 | < 0.001 | ref. | 1396 (86.3) | 133 (64.9) | < 0.001 | ref. | ||
Yes | 293 (16.1) | 50.5 | 0.883 (0.72–1.08) | 0.217 | 221 (13.7) | 72 (35.1) | 1.07 (0.87–1.33) | 0.506 | ||
Nerve invasion | ||||||||||
No | 1465 (80.4) | 60.8 | 0.932 | 1348 (83.4) | 117 (57.1) | < 0.001 | ref. | |||
Yes | 357 (19.6) | 61.1 | 269 (16.6) | 88 (42.9) | 0.86 (0.69–1.06) | 0.152 | ||||
Adipose tissues invasion | ||||||||||
No | 1437 (78.9) | 67.6 | < 0.001 | ref. | ||||||
Yes | 385 (21.1) | 35.6 | 1.31 (1.05–1.65) | 0.019 | ||||||
GBAI | ||||||||||
No | 1617 (88.7) | 63.1 | < 0.001 | ref. | ||||||
Yes | 205 (11.3) | 19.6 | 1.45 (1.12–1.89) | 0.005 | ||||||
Depth of invasion | ||||||||||
T1 | 235 (12.9) | 96.2 | < 0.001 | ref. | 235 (14.5) | 0 (0.0) | < 0.001 | ref. | ||
T2 | 217 (11.9) | 83.4 | 3.35 (1.61–7.98) | 0.001 | 215 (13.3) | 2 (1.0) | 3.36 (1.61–7.00) | 0.001 | ||
T3 | 421 (23.1) | 64.4 | 5.94 (2.99–11.80) | < 0.001 | 377 (23.3) | 44 (21.5) | 6.66 (3.35–13.25) | < 0.001 | ||
T4a | 892 (49.0) | 45.9 | 8.46 (4.30–16.63) | < 0.001 | 744 (46.0) | 148 (72.2) | 9.33 (4.75–18.31) | < 0.001 | ||
T4b | 57 (3.1) | 38.6 | 10.49 (4.95–22.22) | < 0.001 | 46 (2.8) | 11 (5.4) | 10.97 (5.18–23.24) | < 0.001 | ||
Nodal status | ||||||||||
N0 | 561 (30.8) | 80.6 | < 0.001 | ref. | 551 (34.0) | 10 (4.9) | < 0.001 | ref. | ||
N1 | 289 (15.9) | 74.7 | 1.08 (0.80–1.46) | 0.612 | 272 (16.8) | 17 (8.3) | 1.14 (0.84–1.53) | 0.400 | ||
N2 | 306 (16.8) | 61.1 | 1.54 (1.18–2.01) | 0.001 | 273 (16.9) | 33 (16.1) | 1.61 (1.23–2.10) | < 0.001 | ||
N3a | 402 (22.1) | 46.8 | 2.41 (1.89–3.01) | < 0.001 | 336 (20.8) | 66 (32.2) | 2.49 (1.96–3.17) | < 0.001 | ||
N3b | 264 (14.5) | 25.0 | 3.95 (3.04–5.14) | < 0.001 | 185 (11.4) | 79 (38.5) | 4.23 (3.27–5.47) | < 0.001 |