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Table 1 Clinic-pathological characteristics and the univariate and multivariate survival analysis in gastric cancer patients and in patients with GBAI or not

From: Cancer cells invasion to the gastric bare area adipose tissue: a poor prognostic predictor for gastric cancer

Variables

n (%)

5-year survival rate (%)

P

HR (95% CI)

P

Non-GBAI (%)

GBAI

P

HR (95% CI)

P

Gender

 Female

602 (33.0)

60.0

0.580

  

534 (33.0)

68 (33.2)

0.883

  

 Male

1220 (67.0)

61.3

  

1083 (67.0)

137 (66.8)

  

Age (years)

 < 50

478 (26.2)

66.3

0.004

ref.

 

432 (26.7)

46 (22.4)

0.176

  

 ≥ 50

1244 (73.8)

58.9

1.02 (1.01–1.03)

< 0.001

1185 (73.3)

159 (77.6)

  

Tumor size (cm)

 ≤ 5.0

1210 (66.4)

66.5

< 0.001

ref.

 

1112 (68.8)

98 (47.8)

< 0.001

ref.

 

 > 5.0

612 (33.6)

49.7

1.03 (0.89–1.20)

0.668

505 (31.2)

107 (52.2)

1.08 (0.87–1.33)

0.304

Tumor site

 Distal

1006 (55.2)

70.3

< 0.001

ref.

 

954 (59.0)

52 (25.4)

< 0.001

ref.

 

 Proximal/linitis lastica

816 (44.8)

49.3

1.43 (1.23–1.68)

< 0.001

663 (41.0)

153 (74.6)

1.63 (1.40–1.90)

< 0.001

Histological grade

 Well/moderately differentiated

262 (14.4)

69.5

0.234

  

247 (15.3)

15 (7.3)

0.009

ref.

 

 Poorly differentiated

1197 (65.7)

58.3

  

1054 (65.2)

143 (69.8)

1.18 (0.93–1.51)

0.174

 Undifferentiated/signet ring cell carcinoma

363 (19.9)

63.1

  

316 (19.5)

47 (22.9)

1.16 (0.87–1.54)

0.309

Vascular invasion

 No

1529 (83.9)

62.9

< 0.001

ref.

 

1396 (86.3)

133 (64.9)

< 0.001

ref.

 

 Yes

293 (16.1)

50.5

0.883 (0.72–1.08)

0.217

221 (13.7)

72 (35.1)

1.07 (0.87–1.33)

0.506

Nerve invasion

 No

1465 (80.4)

60.8

0.932

  

1348 (83.4)

117 (57.1)

< 0.001

ref.

 

 Yes

357 (19.6)

61.1

  

269 (16.6)

88 (42.9)

0.86 (0.69–1.06)

0.152

Adipose tissues invasion

 No

1437 (78.9)

67.6

< 0.001

ref.

      

 Yes

385 (21.1)

35.6

1.31 (1.05–1.65)

0.019

     

GBAI

 No

1617 (88.7)

63.1

< 0.001

ref.

      

 Yes

205 (11.3)

19.6

1.45 (1.12–1.89)

0.005

     

Depth of invasion

 T1

235 (12.9)

96.2

< 0.001

ref.

 

235 (14.5)

0 (0.0)

< 0.001

ref.

 

 T2

217 (11.9)

83.4

3.35 (1.61–7.98)

0.001

215 (13.3)

2 (1.0)

3.36 (1.61–7.00)

0.001

 T3

421 (23.1)

64.4

5.94 (2.99–11.80)

< 0.001

377 (23.3)

44 (21.5)

6.66 (3.35–13.25)

< 0.001

 T4a

892 (49.0)

45.9

8.46 (4.30–16.63)

< 0.001

744 (46.0)

148 (72.2)

9.33 (4.75–18.31)

< 0.001

 T4b

57 (3.1)

38.6

10.49 (4.95–22.22)

< 0.001

46 (2.8)

11 (5.4)

10.97 (5.18–23.24)

< 0.001

Nodal status

 N0

561 (30.8)

80.6

< 0.001

ref.

 

551 (34.0)

10 (4.9)

< 0.001

ref.

 

 N1

289 (15.9)

74.7

1.08 (0.80–1.46)

0.612

272 (16.8)

17 (8.3)

1.14 (0.84–1.53)

0.400

 N2

306 (16.8)

61.1

1.54 (1.18–2.01)

0.001

273 (16.9)

33 (16.1)

1.61 (1.23–2.10)

< 0.001

 N3a

402 (22.1)

46.8

2.41 (1.89–3.01)

< 0.001

336 (20.8)

66 (32.2)

2.49 (1.96–3.17)

< 0.001

 N3b

264 (14.5)

25.0

3.95 (3.04–5.14)

< 0.001

185 (11.4)

79 (38.5)

4.23 (3.27–5.47)

< 0.001