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Table 3 Risk factors for development of recurrence tumor after surgical resection of IPMN and MCN on the univariate and multivariate analyses (n = 245)

From: The pathological features and prognoses of intraductal papillary mucinous neoplasm and mucinous cystic neoplasm after surgical resection: a single institution series

  Univariate analysis Multivariate analysis
Recurrence (+) n = 37 Recurrence (−) n = 208 p value p Odds ratio (OR) 95% confidence interval
Age, median years (IQR) 64 (54.5–71) 63 (54–70) 0.43    
Sex, male, % (n) 59.5 (22) 61.1 (127) 0.85    
Diabetes mellitus, % (n) 32.4 (12) 19.7 (41) 0.08 0.32   
Pathological diagnoses
 Malignant, % (n) 67.6 (25) 32.7 (68) < 0.0001 < 0.0001 3.65 2.2–6.5
Tumor size, median mm (IQR) 50 (30–70) 40 (24–70) 0.49    
Morphological type for IPMN, n = 218, recurrence (n = 34)
 Branch duct type, % (n) 17.6 (6) 15.2 (28) 0.72    
Epithelial subtype for IPMN, n = 218, recurrence (n = 34)
 Gastric type, % (n) 32.4 (11) 43.5 (80) 0.41    
 Intestinal type, % (n) 35.3 (12) 37.5 (69) 0.81    
 Pancreatobiliary type, % (n) 11.8 (4) 12.0 (22) 0.98    
 Oncocytic type, % (n) 14.7 (5) 2.2 (4) 0.01 0.031 1.69 1.13–1.97
 Mixed type, % (n) 5.9 (2) 4.9 (9) 1.0    
Resection procedure
 TP, % (n) 5.4 (2) 6.3 (13) 1.0    
 PD, % (n) 75.7 (28) 53.8 (112) 0.013 0.12   
 DP, % (n) 16.2 (6) 12.5 (26) 0.54    
 CP, % (n) 2.7 (1) 7.7 (16) 0.45    
 Enucleation, % (n) 0 (0) 1.9 (4) 1.0    
Peripheral invasion, % (n) 73.0 (27) 4.8 (10) < 0.0001 < 0.0001 12.87 1.87–24.03
Margin status
 Margin with noninvasive component, % (n) 13.5 (5) 14.9 (31) 0.82    
 Margin with invasive component, % (n) 13.5 (5) 2.4 (5) 0.02 0.039 1.99 1.08–3.06
  1. IPMN intraductal papillary mucinous neoplasm, IQR interquartile range, DP distal pancreatectomy, PD pancreaticoduodenectomy, TP total pancreatectomy, CP central pancreatectomy