Table 3 Risk factors for development of recurrence tumor after surgical resection of IPMN and MCN on the univariate and multivariate analyses (n = 245)
Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
Recurrence (+) n = 37 | Recurrence (−) n = 208 | p value | p | Odds ratio (OR) | 95% confidence interval | |
Age, median years (IQR) | 64 (54.5–71) | 63 (54–70) | 0.43 | |||
Sex, male, % (n) | 59.5 (22) | 61.1 (127) | 0.85 | |||
Diabetes mellitus, % (n) | 32.4 (12) | 19.7 (41) | 0.08 | 0.32 | ||
Pathological diagnoses | ||||||
Malignant, % (n) | 67.6 (25) | 32.7 (68) | < 0.0001 | < 0.0001 | 3.65 | 2.2–6.5 |
Tumor size, median mm (IQR) | 50 (30–70) | 40 (24–70) | 0.49 | |||
Morphological type for IPMN, n = 218, recurrence (n = 34) | ||||||
Branch duct type, % (n) | 17.6 (6) | 15.2 (28) | 0.72 | |||
Epithelial subtype for IPMN, n = 218, recurrence (n = 34) | ||||||
Gastric type, % (n) | 32.4 (11) | 43.5 (80) | 0.41 | |||
Intestinal type, % (n) | 35.3 (12) | 37.5 (69) | 0.81 | |||
Pancreatobiliary type, % (n) | 11.8 (4) | 12.0 (22) | 0.98 | |||
Oncocytic type, % (n) | 14.7 (5) | 2.2 (4) | 0.01 | 0.031 | 1.69 | 1.13–1.97 |
Mixed type, % (n) | 5.9 (2) | 4.9 (9) | 1.0 | |||
Resection procedure | ||||||
TP, % (n) | 5.4 (2) | 6.3 (13) | 1.0 | |||
PD, % (n) | 75.7 (28) | 53.8 (112) | 0.013 | 0.12 | ||
DP, % (n) | 16.2 (6) | 12.5 (26) | 0.54 | |||
CP, % (n) | 2.7 (1) | 7.7 (16) | 0.45 | |||
Enucleation, % (n) | 0 (0) | 1.9 (4) | 1.0 | |||
Peripheral invasion, % (n) | 73.0 (27) | 4.8 (10) | < 0.0001 | < 0.0001 | 12.87 | 1.87–24.03 |
Margin status | ||||||
Margin with noninvasive component, % (n) | 13.5 (5) | 14.9 (31) | 0.82 | |||
Margin with invasive component, % (n) | 13.5 (5) | 2.4 (5) | 0.02 | 0.039 | 1.99 | 1.08–3.06 |