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Table 1 Demographic and clinicopathological features of the study cohort

From: The pathological features and prognoses of intraductal papillary mucinous neoplasm and mucinous cystic neoplasm after surgical resection: a single institution series

Demographics IPMN MCN IPMN vs MCN
All Noninvasive Malignant p valuea All Noninvasive Malignant p valueb p valuec
Total subjects, (n) 218 125 93   27 19 8   
Age, median (IQR) 63.0 (56.0–70.0) 63.0 (55.5–70.0) 64.0 (56.5–71.0) 0.45 54.0 (41.0–60.0) 53.0 (35.0–57.0) 57.0 (49.0–71.3) 0.12 < 0.0001
Female, % (n) 32.1 (70) 30.4 (38) 34.4 (32) 0.53 100 (27) 100 (19) 100 (8) < 0.0001 < 0.0001
Diabetes mellitus, % (n) 24.3 (53) 15.2 (19) 36.6 (34) < 0.0001 18.5 (5) 15.8 (3) 25 (2) 0.62 0.5
Surgical resections and pathological outcomes
Resection procedure, % (n)
  TP 6.9 (15) 4.8 (6) 9 (9.7) 0.16 0 (0) 0 (0) 0 (0) - 0.39
  PD 64.2 (140) 58.4 (73) 69.1 (67) 0.04 14.8 (4) 10.2 (2) 25 (2) 0.56 < 0.0001
  DP 19.3 (42) 25.6 (32) 10.8 (10) 0.006 81.5 (22) 89.8 (17) 63 (5) 0.14 < 0.0001
  CP 7.8 (17) 8.0 (10) 7.5 (7) 0.9 0 (0) 0 (0) 0 (0) - 0.23
  Enucleation 1.8 (4) 3.2 (4) 0 (0) 0.14 3.7 (1) 0 (0) 13 (1) 0.32 0.45
  Tumor size (mm), median (IQR) 40(23.8-70) 38 (21.5–75) 40 (27.5–67.5) 0.89 45 (35–65) 40 (35–55) 58.5 (35–68.8) 0.39 0.89
  Morphological type for IPMN (BD/MD/MT), n 34/80/104 21/59/45 13/21/59 0.57      
  Epithelial subtype for IPMN (G/I/P/O/M), n 91/81/26/9/11 54/47/8/2/4 27/34/18/7/7 0.006      
Peripheral invasion, %(n)
  Perineural invasion 12.8 (28) 0 (0) 30.1 (28)   14.8 (4) 0 (0) 50.0 (4)   1.0
  Vascular invasion 8.3 (18) 0 (0) 19.4 (18)   0 (0) 0 (0) 0 (0)   0.23
  Cancerization of ducts 5.5 (12) 0 (0) 12.9 (12)   7.4 (2) 0 (0) 25.0 (2)   1.0
  Lymphatic metastasis 6.4 (14) 0 (0) 15.1 (14)   14.8 (4) 0 (0) 50.0 (4)   0.24
  Common bile duct invasion 3.7 (8) 0 (0) 8.6 (8)   3.7 (1) 0(0) 12.5(1)   1.0
  Peripancreatic fat invasion 10.6 (23) 0 (0) 24.7 (23)   7.4 (2) 0 (0) 25.0 (2)   1.0
  Duodenum invasion 6.4 (14) 0 (0) 15.1 (14)   0 (0) 0 (0) 0 (0)   0.38
Margin status
  Negative 80.3 (175) 88.8 (111) 68.2 (64) < 0.0001 88.9 (24) 19 (100) 62.5 (5) 0.019 0.41
  Noninvasive component 16.5 (36) 11.2 (14) 23.7 (22) 0.014 0 (0) 0 (0) 0 (0) - 0.018
  Invasive component 3.2 (7) 0 (0) 7.5 (7) < 0.0001 11.1 (3) 0 (0) 37.5 (3) 0.19 0.003
  1. IQR interquartile range, DP distal pancreatectomy, PD pancreaticoduodenectomy, TP total pancreatectomy, CP central pancreatectomy, MCN mucinous cystic neoplasm, IPMN intraductal papillary mucinous neoplasm, BD/MD/MT branch duct/main duct/mixed type, G/I/P/O/M gastric/intestinal/pancreatobiliary/oncocytic/mixed type
  2. aComparison of invasive vs non-invasive IPMN
  3. bComparison of invasive vs non-invasive MCN
  4. cComparison of total IPMN vs total MCN