Table 1 Demographic and clinicopathological features of the study cohort
Demographics | IPMN | MCN | IPMN vs MCN | ||||||
|---|---|---|---|---|---|---|---|---|---|
All | Noninvasive | Malignant | p valuea | All | Noninvasive | Malignant | p valueb | p valuec | |
Total subjects, (n) | 218 | 125 | 93 | 27 | 19 | 8 | |||
Age, median (IQR) | 63.0 (56.0–70.0) | 63.0 (55.5–70.0) | 64.0 (56.5–71.0) | 0.45 | 54.0 (41.0–60.0) | 53.0 (35.0–57.0) | 57.0 (49.0–71.3) | 0.12 | < 0.0001 |
Female, % (n) | 32.1 (70) | 30.4 (38) | 34.4 (32) | 0.53 | 100 (27) | 100 (19) | 100 (8) | < 0.0001 | < 0.0001 |
Diabetes mellitus, % (n) | 24.3 (53) | 15.2 (19) | 36.6 (34) | < 0.0001 | 18.5 (5) | 15.8 (3) | 25 (2) | 0.62 | 0.5 |
Surgical resections and pathological outcomes | |||||||||
Resection procedure, % (n) | |||||||||
TP | 6.9 (15) | 4.8 (6) | 9 (9.7) | 0.16 | 0 (0) | 0 (0) | 0 (0) | - | 0.39 |
PD | 64.2 (140) | 58.4 (73) | 69.1 (67) | 0.04 | 14.8 (4) | 10.2 (2) | 25 (2) | 0.56 | < 0.0001 |
DP | 19.3 (42) | 25.6 (32) | 10.8 (10) | 0.006 | 81.5 (22) | 89.8 (17) | 63 (5) | 0.14 | < 0.0001 |
CP | 7.8 (17) | 8.0 (10) | 7.5 (7) | 0.9 | 0 (0) | 0 (0) | 0 (0) | - | 0.23 |
Enucleation | 1.8 (4) | 3.2 (4) | 0 (0) | 0.14 | 3.7 (1) | 0 (0) | 13 (1) | 0.32 | 0.45 |
Tumor size (mm), median (IQR) | 40(23.8-70) | 38 (21.5–75) | 40 (27.5–67.5) | 0.89 | 45 (35–65) | 40 (35–55) | 58.5 (35–68.8) | 0.39 | 0.89 |
Morphological type for IPMN (BD/MD/MT), n | 34/80/104 | 21/59/45 | 13/21/59 | 0.57 | |||||
Epithelial subtype for IPMN (G/I/P/O/M), n | 91/81/26/9/11 | 54/47/8/2/4 | 27/34/18/7/7 | 0.006 | |||||
Peripheral invasion, %(n) | |||||||||
Perineural invasion | 12.8 (28) | 0 (0) | 30.1 (28) | 14.8 (4) | 0 (0) | 50.0 (4) | 1.0 | ||
Vascular invasion | 8.3 (18) | 0 (0) | 19.4 (18) | 0 (0) | 0 (0) | 0 (0) | 0.23 | ||
Cancerization of ducts | 5.5 (12) | 0 (0) | 12.9 (12) | 7.4 (2) | 0 (0) | 25.0 (2) | 1.0 | ||
Lymphatic metastasis | 6.4 (14) | 0 (0) | 15.1 (14) | 14.8 (4) | 0 (0) | 50.0 (4) | 0.24 | ||
Common bile duct invasion | 3.7 (8) | 0 (0) | 8.6 (8) | 3.7 (1) | 0(0) | 12.5(1) | 1.0 | ||
Peripancreatic fat invasion | 10.6 (23) | 0 (0) | 24.7 (23) | 7.4 (2) | 0 (0) | 25.0 (2) | 1.0 | ||
Duodenum invasion | 6.4 (14) | 0 (0) | 15.1 (14) | 0 (0) | 0 (0) | 0 (0) | 0.38 | ||
Margin status | |||||||||
Negative | 80.3 (175) | 88.8 (111) | 68.2 (64) | < 0.0001 | 88.9 (24) | 19 (100) | 62.5 (5) | 0.019 | 0.41 |
Noninvasive component | 16.5 (36) | 11.2 (14) | 23.7 (22) | 0.014 | 0 (0) | 0 (0) | 0 (0) | - | 0.018 |
Invasive component | 3.2 (7) | 0 (0) | 7.5 (7) | < 0.0001 | 11.1 (3) | 0 (0) | 37.5 (3) | 0.19 | 0.003 |