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Table 5 The prognostic factors for unconventional metastatic patients in the RRG group

From: Regional metastasis to anatomies beyond traditional neck dissection boundaries: a multi-institutional analysis focused on unconventional metastases in oral cancer patients

Variables The overall survival rate P value
Univariate analysis Cox modelb
Age   0.500 NA
 33–59(25) 16.0%
 60–87(11) 9.1%
Gender   0.286 NA
 Male(24) 12.5%
 Female(12) 16.7%
Histories of smoking and alcohol 10.0% 0.248 NA
 Yes(20) 10.0%
 No(16) 12.5%
Premalignant mucosal diseases   0.484 NA
 Yes(8) 12.5%
 No(28) 14.3%
Prior radio- or chemo-therapies   0.809 NA
 Yes(21) 19.0%
 No(15) 6.7%
Primary site   0.838 NA
 Buccal mucosa(5) 40.0%
 Upper gingiva(7) 14.3%
 Lower gingiva(5) 20.0%
 Floor of mouth(3) 33.3%
 Retromolar trigone(8) None
 Tongue(7) None
 Hard palate(1) None
Unconventional metastatic subsites   0.122 NA
 Buccinator (16) 18.8%
 Sublingual(11) 9.1%
 Parotida(9) 11.1%
Pathological grade   0.172 NA
 II(19) 26.3%
 III(17) None
Pathological grade is upgraded compared to the last surgery   0.404 NA
 Yes(16) 6.3%
 No(20) 20.0%
Number of metastatic lymph nodes in the unconventional subsites   0.617 NA
 1(29) 13.8%
 2(6) 16.7%
 3(1) None
Lymph nodes size of UMLNs   0.808 NA
 0–3 cm(22) 9.1%
 > 3 cm(14) 21.4%
Last neck dissections   0.407 NA
 ISND(13) 7.7%
 IRND(12) 25.0%
 BND(1) None
 No treatment(10) 10.0%
Neck dissections this time   0.426 NA
 ISND(5) 20.0%
 IRND(7) 14.3%
 CND(8) None
 BND(9) None
 No treatment(7) 42.9%
Extranodal extension (ENE) in UMLNs   0.290 NA
 Yes(16) 18.8%
 No(20) 10.0%
Contralateral metastasis   0.124 NA
 Yes(13) None
 No(23) 21.7%
Cervical lymph node metastasis   0.066 NA
 Yes(22) None
 No(14) 35.7%
Extranodal extension (ENE) in cervical lymph nodes   0.030 0.030
 Yes(10) None
 No(26) 19.2%
Postoperative adjuvant therapies   0.719 NA
 Radiotherapy(13) 15.4%
 Chemotherapy(3) None
 Radio-chemotherapies(8) 12.5%
 None(12) 16.7%
  1. NA not available
  2. aIncluding a case which is with both buccinator and parotid metastases,but mostly in the parotid
  3. bCox analysis for RRG group only