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Table 4 The prognostic factors for unconventional metastatic patients in the SG group

From: Regional metastasis to anatomies beyond traditional neck dissection boundaries: a multi-institutional analysis focused on unconventional metastases in oral cancer patients

Variables The overall survival rate P value
Univariate analysis Cox modela
Age   0.347 NA
 33–59(16) 56.3%
 60–87(12) 50.0%
Gender   0.541 NA
 Male(17) 58.8%
 Female(11) 45.5%
Histories of smoking or alcohol   0.363 NA
 Yes(16) 62.5%
 No(12) 41.7%
Premalignant mucosal diseases   0.530 NA
 Yes(7) 57.1%
 No(21) 52.4%
Primary site   0.678 NA
 Buccal mucosa(1) 100.0%
 Carcinoma of lip(2) 100.0%
 Upper gingiva(5) 60%
 Lower gingiva(2) None
 Floor of mouth(2) None
 Tongue(6) 50.0%
 Hard palate(10) 60.0%
Unconventional metastatic subsites   0.810 NA
 Buccinator (19) 57.9%
 Sublingual(8) 37.5%
 Parotid(1) 100%
Pathological grade   0.890 NA
 I(4) 50.0%
 II(19) 52.6%
 III(5) 60.0%
Pathological grade is upgraded compared to the last surgery   0.929 NA
 Yes(5) 60.0%
 No(23) 52.2%
Number of metastatic lymph nodes in the unconventional subsites   0.344 NA
 1(20) 60.0%
 2(8) 37.5%
Lymph nodes size of UMLNs   0.026 NA
 0–3 cm(21) 61.9%
 > 3 cm(7) 28.6%
Extranodal extension (ENE) in UMLNs   0.015 0.017
 Yes(8) 25.0%
 No(20) 65.0%
Contralateral metastasis   0.006 NA
 Yes(7) 14.3%
 No(21) 66.7%
Cervical lymph node metastasis   0.046 NA
 Yes(17) 35.3%
 No(11) 81.8%
Neck dissections   0.018 0.001
 ISND(4) 75.0%
 IRND(16) 68.8%
 BND(8) 12.5%
Extranodal extension (ENE) in cervical lymph nodes   0.025 NA
 Yes(3) None
 No(25) 60.0%
Postoperative adjuvant therapies   0.100 NA
 Radiotherapy(15) 66.7%
 Radio-chemotherapies(9) 44.4%
 None(4) 25.0%
  1. NA not available
  2. aCox analysis for SG group only