Table 3 The prognostic factors for unconventional metastatic patients in the PG group
Variables | The overall survival rate | p Value | |
|---|---|---|---|
Univariate Analysis | Cox Modela | ||
Age | Â | 0.347 | NA |
 31–59(11) | 45.5% | ||
 60–87(14) | 64.3% | ||
Gender | Â | 0.968 | NA |
 Male(13) | 53.8% | ||
 Female(12) | 58.3% | ||
Histories of smoking or alcohol | Â | 0.617 | NA |
 Yes(13) | 61.5% | ||
 No(12) | 50.0% | ||
Premalignant mucosal diseases | Â | 0.957 | NA |
 Yes(12) | 58.3% | ||
 No(13) | 53.8% | ||
Primary site | Â | 0.251 | NA |
 Buccal mucosa(1) | None | ||
 Upper gingiva(1) | None | ||
 Lower gingiva(5) | 80.0% | ||
 Tongue(11) | 54.5% | ||
 Carcinoma of lip(4) | 33.3% | ||
 Retromolar trigone(1) | None | ||
 Hard palate(2) | 50.0% | ||
Unconventional metastatic subsites | Â | 0.183 | NA |
 Buccinator (10) | 60.0% | ||
 Sublingual(12) | 66.7% | ||
 Parotid(3) | None | ||
Pathological grade | Â | 0.009 | NA |
 II(17) | 29.4% | ||
 III(8) | 25.0% | ||
TNM staging | Â | 0.197 | NA |
 T1/T2(6) | 100.0% | ||
 T3/T4(19) | 42.1% | ||
Number of metastatic lymph nodes in the unconventional sites | Â | 0.037 | NA |
 1(19) | 68.4% | ||
 2(6) | 16.7% | ||
Lymph nodes size of UMLNs | Â | 0.041 | NA |
 0–3 cm(22) | 63.6% | ||
 > 3 cm(3) | None | ||
Extranodal extension (ENE) in UMLNs | Â | 0.013 | NA |
 Yes(4) | None | ||
 No(21) | 66.7% | ||
Contralateral metastasis | Â | 0.019 | NA |
 Yes(7) | 28.6% | ||
 No(18) | 66.7% | ||
Cervical lymph node metastasis | Â | 0.197 | NA |
 Yes(19) | 42.1% | ||
 No(6) | 100.0% | ||
Neck dissections | Â | 0.010 | NA |
 ISND(9) | 77.8% | ||
 IRND(8) | 62.5% | ||
 BND(8) | 25.0% | ||
Extranodal extension (ENE) in cervical lymph nodes | Â | 0.002 | 0.006 |
 Yes(8) | 12.5% | ||
 No(17) | 76.5% | ||
Postoperative adjuvant therapies | Â | 0.470 | NA |
 Radiotherapy(13) | 53.8% | ||
 Radio-chemotherapies(8) | 37.5% | ||
 None(4) | 16.7% | ||
sDepth of invasion | Â | Â | Â |
 > 10 mm(12) | 25% | 0.014 | 0.021 |
 < 10 mm(13) | 84.6% | ||
Perineural invasion (PNI) | Â | Â | Â |
 Yes(9) | 22.2% | 0.016 | NA |
 No(16) | 75.0% | ||