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Table 3 The prognostic factors for unconventional metastatic patients in the PG group

From: Regional metastasis to anatomies beyond traditional neck dissection boundaries: a multi-institutional analysis focused on unconventional metastases in oral cancer patients

Variables The overall survival rate p Value
Univariate Analysis Cox Modela
Age   0.347 NA
 31–59(11) 45.5%
 60–87(14) 64.3%
Gender   0.968 NA
 Male(13) 53.8%
 Female(12) 58.3%
Histories of smoking or alcohol   0.617 NA
 Yes(13) 61.5%
 No(12) 50.0%
Premalignant mucosal diseases   0.957 NA
 Yes(12) 58.3%
 No(13) 53.8%
Primary site   0.251 NA
 Buccal mucosa(1) None
 Upper gingiva(1) None
 Lower gingiva(5) 80.0%
 Tongue(11) 54.5%
 Carcinoma of lip(4) 33.3%
 Retromolar trigone(1) None
 Hard palate(2) 50.0%
Unconventional metastatic subsites   0.183 NA
 Buccinator (10) 60.0%
 Sublingual(12) 66.7%
 Parotid(3) None
Pathological grade   0.009 NA
 II(17) 29.4%
 III(8) 25.0%
TNM staging   0.197 NA
 T1/T2(6) 100.0%
 T3/T4(19) 42.1%
Number of metastatic lymph nodes in the unconventional sites   0.037 NA
 1(19) 68.4%
 2(6) 16.7%
Lymph nodes size of UMLNs   0.041 NA
 0–3 cm(22) 63.6%
 > 3 cm(3) None
Extranodal extension (ENE) in UMLNs   0.013 NA
 Yes(4) None
 No(21) 66.7%
Contralateral metastasis   0.019 NA
 Yes(7) 28.6%
 No(18) 66.7%
Cervical lymph node metastasis   0.197 NA
 Yes(19) 42.1%
 No(6) 100.0%
Neck dissections   0.010 NA
 ISND(9) 77.8%
 IRND(8) 62.5%
 BND(8) 25.0%
Extranodal extension (ENE) in cervical lymph nodes   0.002 0.006
 Yes(8) 12.5%
 No(17) 76.5%
Postoperative adjuvant therapies   0.470 NA
 Radiotherapy(13) 53.8%
 Radio-chemotherapies(8) 37.5%
 None(4) 16.7%
sDepth of invasion    
 > 10 mm(12) 25% 0.014 0.021
 < 10 mm(13) 84.6%
Perineural invasion (PNI)    
 Yes(9) 22.2% 0.016 NA
 No(16) 75.0%
  1. NA not available
  2. aCox analysis for PG group only