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Table 1 Patient demographics and tumor characteristics

From: Regional metastasis to anatomies beyond traditional neck dissection boundaries: a multi-institutional analysis focused on unconventional metastases in oral cancer patients

Variables N(%) The overall survival rate Univariate analysis
Age    0.086
 31–59 37(41.6) 43.2
 60–87 52(58.4) 34.6
Gender    0.500
 Male 54(60.7) 37.0
 Female 35(39.3) 40.0
Histories of smoking and alcohol    0.867
 Yes 49(55.1) 55.1
 No 40(44.9) 35.0
Premalignant mucosal diseases    0.257
 Yes 27(30.3) 30.3
 No 62(69.7) 35.5
Prior radio- or chemo-therapies    0.011
 Yes 22(24.7) 24.7
 No 67(75.3) 43.3
Treatment status    < 0.001
 Primary lesions for treatment (PG) 25(28.1) 56.0
 Staged (secondary) neck dissections (SG) 28(31.5) 53.6
 Recurrent or residual lesions for salvage surgery (RRG) 36(43.8) 13.9
Primary or recurrent site    0.005
 Buccal mucosa 7(7.9) 42.9
 Upper gingiva 13(14.6) 30.8
 Lower gingiva 12(13.5) 41.7
 Floor of mouth 5(5.6) 20.0
 Tongue 24(27.0) 37.5
 Retromolar trigone 9(10.1) 0.0
 Lip 6(6.7) 83.3
 Hard palate 13(14.6) 53.8
Unconventional metastatic subsites    0.008
 Buccinator 45(50.6) 44.4
 Sublingual 31(34.8) 38.7
 Parotida 13(14.6) 15.4
Pathological grade    0.002
 I 4(4.5) 50.0
 II 55(61.8) 49.1
 III 30(33.7) 16.7
Number of metastatic lymph nodes in the unconventional subsites   0.087
 1 68(76.4) 42.6
 2 20(22.5) 25.0
 3 1(1.1) 0.0
Lymph nodes size of UMLNs    0.003
 0–3 cm 65(73.0) 44.6
 > 3 cm 24(27.0) 20.8
Extranodal extension (ENE) in UMLNs    < 0.001
 Yes 28(31.5) 17.9
 No 61(68.5) 47.5
Contralateral metastasis    < 0.001
 Yes 27(30.3) 30.3
 No 62(69.7) 50.0
Concurrent with cervical lymph node metastases    0.003
 Yes 58(65.2) 65.2
 No 31(34.8) 64.5
Extranodal extension (ENE) in cervical lymph nodes    < 0.001
 Yes 21(23.6) 23.6
 No 68(76.4) 48.5
Neck dissection    < 0.001
 ISND 18(20.2) 61.1
 IRND 31(34.8) 54.8
 CND 8(9.0) 0.0
 BND 25(28.1) 12.0
 None 7(7.9) 42.9
Anti-EGFR therapy    0.957
 Yes 16(18.0) 31.3
 No 73(82.0) 39.7
Postoperative adjuvant therapies    0.042
 Radiotherapy 41(46.1) 46.3
 Chemotherapy 3(3.4) 0.0
 Radio-chemotherapies 25(28.1) 32.0
 None 20(22.5) 35.0
  1. NA not available
  2. aIncluding a case which is with both buccinator and parotid metastases,but mostly in the parotid