Variable | Aged < 70 years (n = 651) | Aged ≥ 70 years (n = 73) | P value | Standardized mean difference |
---|---|---|---|---|
Combined with RFA | 85 (13.1%) | 3 (4.1%) | 0.027 | 0.486 |
Two-stage hepatectomy | 9 (1.4%) | 1 (1.4%) | 1.000 | |
Simultaneous resection | 120 (18.4%) | 17 (23.3%) | 0.315 | |
Major hepatectomy | 127 (19.5%) | 9 (12.3%) | 1.136 | 0.127 |
Pringle clamp | 513 (78.8%) | 53 (72.6%) | 0.224 | |
Pringle clamp time (min) | 20 (0–98) | 15 (0–60) | 0.061 | |
R1 margin | 96 (14.7%) | 7 (9.6%) | 0.232 | |
Intraoperative blood loss (ml) | 200 (0–6500) | 150 (20–1000) | 0.529 | |
Intraoperative RBC transfusion | 28 (4.3%) | 5 (6.8%) | 0.367 | |
Intraoperative RBC transfused (U) | 4 (1–12) | 3 (2–4) | 0.269 | |
Operation time (min) | 187 (32–600) | 180 (60–330) | 0.146 | |
Hospital stay (days) | 9 (4–78) | 9 (4–48) | 0.909 | |
Postoperative complications | 186 (28.6%) | 20 (27.4%) | 0.833 | |
Clavien-Dindo classification | 0.262 | |||
I–II | 106 (57.0%) | 14 (70.0%) | ||
III–V | 80 (43.0%) | 6 (30.0%) | ||
General complications | 58 (8.9%) | 4 (5.5%) | 0.321 | |
Postoperative heart failure | 2 (0.3%) | 0 (0%) | 1.000 | |
Postoperative coronary artery disease | 6 (0.9%) | 0 (0%) | 1.000 | |
Postoperative arrhythmia | 8 (1.2%) | 1 (1.4%) | 1.000 | |
Postoperative lung infection | 5 (0.8%) | 1 (1.4%) | 0.473 | |
Postoperative renal failure | 2 (0.3%) | 0 (0%) | 1.000 | |
Postoperative pulmonary embolism | 1 (0.2%) | 0 (0%) | 1.000 | |
Postoperative deep vein thrombosis | 2 (0.3%) | 0 (0%) | 1.000 | |
Postoperative urinary infection | 4 (0.6%) | 0 (0%) | 1.000 | |
Postoperative pleural effusion | 28 (4.3%) | 2 (2.7%) | 0.759 | |
Postoperative stress ulcer | 6 (0.9%) | 1 (1.4%) | 0.526 | |
Surgical complications | 129 (19.8%) | 11 (15.1%) | 0.330 | |
Posthepatectomy liver failure | 22 (3.4%) | 2 (2.7%) | 1.000 | |
Postoperative abdominal infection | 53 (8.1%) | 7 (9.6%) | 0.671 | |
Postoperative bile leakage | 37 (5.7%) | 3 (4.1%) | 0.788 | |
Postoperative abdominal collection | 22 (3.4%) | 2 (2.7%) | 1.000 | |
Incision infection | 9 (1.4%) | 0 (0%) | 0.610 | |
Postoperative ileus | 12 (1.8%) | 0 (0%) | 0.622 | |
Postoperative abdominal bleeding | 26 (4.0%) | 1 (1.4%) | 0.508 | |
ICU | 18 (2.8%) | 8 (11.0%) | 0.003 | |
ICU stay (days) | 1 (1–6) | 1.5 (1–6) | 0.927 | |
Postoperative RBC transfusion | 50 (7.7%) | 7 (9.6%) | 0.566 | |
Postoperative RBC transfused (U) | 4 (2–58) | 2 (2–6) | 0.510 | |
Reoperation | 12 (1.8%) | 0 (0%) | 0.622 | |
Readmission | 3 (0.5%) | 3 (4.1%) | 0.016 | |
Mortality (in-hospital) | 1 (0.2%) | 0 (0%) | 1.000 | |
Mortality (90-day) | 1 (0.2%) | 0 (0%) | 1.000 | |
Recurrence | 467 (71.7%) | 49 (67.1%) | 0.409 | |
Intrahepatic recurrence | 355 (54.5%) | 40 (54.8%) | 0.966 | |
Extrahepatic recurrence | 112 (17.2%) | 9 (12.3%) | 0.290 | |
Disease-free survival | 0.374 | |||
1-year | 46.6% | 50.5% | ||
3-year | 26.2% | 31.0% | ||
5-year | 23.5% | 25.5% | ||
Overall survival | 0.219 | |||
1-year | 94.1% | 90.4% | ||
3-year | 60.5% | 56.3% | ||
5-year | 48.7% | 43.6% | ||
Cancer-specific survival | 0.512 | |||
1-year | 94.4% | 90.4% | ||
3-year | 61.1% | 59.0% | ||
5-year | 49.2% | 45.7% |