Prognostic value of preoperative lymphocyte-related systemic inflammatory biomarkers in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: a systematic review and meta-analysis

Table 2 Subgroup analysis for NLR in UTUC patients

Subgroup	No. of studies	No. of patients	HR (95% CI)	P value	Heterogeneity		Effect model
Subgroup	No. of studies	No. of patients	HR (95% CI)	P value	I² (%)	Ph	Effect model
Overall	17	8672	1.66 (1.39–1.98)	< 0.001	53	0.006	Random
Region
Europe	2	2476	1.58 (0.64–3.88)	0.32	80	0.02	Random
Asia	15	6196	1.73 (1.52–1.96)	< 0.001	17	0.26	Fixed
Sample size
≥ 200	13	8110	1.58 (1.31–1.91)	< 0.001	57	0.006	Random
< 200	4	562	2.28 (1.49–3.28)	< 0.001	0	0.43	Fixed
Median age (years)
≥ 70	5	1818	1.59 (1.25–2.03)	< 0.001	0	0.43	Fixed
< 70	11	6620	1.62 (1.30–2.01)	< 0.001	60	0.005	Random
Cutoff value of NLR
> 2.70	6	1986	1.60 (1.26–2.02)	< 0.001	0	0.42	Fixed
≤ 2.70	11	6686	1.78 (1.53–2.07)	< 0.001	8	0.37	Fixed
Median time of follow-up (months)
≥ 36	11	6692	1.77 (1.41–2.22)	< 0.001	61	0.004	Random
< 36	5	1890	1.47 (1.16–1.87)	0.002	49	0.10	Fixed
Quality of study
High	16	8582	1.67 (1.39–2.01)	< 0.001	56	0.003	Random
Moderate	1	90	-	-	-	-	-

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