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Table 2 Subgroup analysis for NLR in UTUC patients

From: Prognostic value of preoperative lymphocyte-related systemic inflammatory biomarkers in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: a systematic review and meta-analysis

Subgroup No. of studies No. of patients HR (95% CI) P value Heterogeneity Effect model
I2 (%) Ph
Overall 17 8672 1.66 (1.39–1.98) < 0.001 53 0.006 Random
Region
 Europe 2 2476 1.58 (0.64–3.88) 0.32 80 0.02 Random
 Asia 15 6196 1.73 (1.52–1.96) < 0.001 17 0.26 Fixed
Sample size
 ≥ 200 13 8110 1.58 (1.31–1.91) < 0.001 57 0.006 Random
 < 200 4 562 2.28 (1.49–3.28) < 0.001 0 0.43 Fixed
Median age (years)
 ≥ 70 5 1818 1.59 (1.25–2.03) < 0.001 0 0.43 Fixed
 < 70 11 6620 1.62 (1.30–2.01) < 0.001 60 0.005 Random
Cutoff value of NLR
 > 2.70 6 1986 1.60 (1.26–2.02) < 0.001 0 0.42 Fixed
 ≤ 2.70 11 6686 1.78 (1.53–2.07) < 0.001 8 0.37 Fixed
Median time of follow-up (months)
 ≥ 36 11 6692 1.77 (1.41–2.22) < 0.001 61 0.004 Random
 < 36 5 1890 1.47 (1.16–1.87) 0.002 49 0.10 Fixed
Quality of study
 High 16 8582 1.67 (1.39–2.01) < 0.001 56 0.003 Random
 Moderate 1 90 - - - - -