Prognostic value of preoperative lymphocyte-related systemic inflammatory biomarkers in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: a systematic review and meta-analysis

Shao, Yuan; Li, Wenxia; Wang, Dongwen; Wu, Bo

doi:10.1186/s12957-020-02048-7

Table 1 Characteristics of the studies included in the meta-analysis

From: Prognostic value of preoperative lymphocyte-related systemic inflammatory biomarkers in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: a systematic review and meta-analysis

Author and year	Period	Region	Sample size	Gender (M/F)	Median age	Type of biomarker	Cutoff value			Surgery	NAC	AC	Outcome	Follow-up (months)	NOS score
Author and year	Period	Region	Sample size	Gender (M/F)	Median age	Type of biomarker	NLR	PLR	MLR	Surgery	NAC	AC	Outcome	Follow-up (months)	NOS score
Xu et al. 2020 [24]	2003–2016	China	703	399/304	67	NLR	2.5	-	-	RNU	0	287	OS, CSS, RFS	42 (1–168)	7
Jan et al. 2019 [13]	2007–2017	Taiwan	424	189/235	70	NLR, PLR, MLR	4.0	150	0.4	RNU	0	40	OS, CSS, PFS	35 (14–60)	7
Kuroda et al. 2019 [14]	1999–2017	Japan	187	138/49	71	NLR, PLR	2.035	165	-	RNU	4	53	CSS, RFS	Mean = 49.2 (3.4-209.2)	7
Li et al. 2019 [25]	2008–2017	China	704	401/303	Mean = 66	MLR	-	-	3.6	RNU	0	286	OS, CSS, RFS	36 (34–43)	7
Zheng et al. 2019 [15]	2005–2015	China	259	185/74	Mean = 67.5	NLR, PLR, MLR	2.53	126.88	0.35	RNU	0	28	OS, CSS, MFS	33.3 (15.5–64.2)	8
Kohada et al. 2018 [26]	1999–2016	Japan	148	112/36	Mean = 71	NLR	3.0	-	-	RNU	0	25	CSS, RFS	35.5	7
Nishikawa et al. 2018 [27]	2005–2015	Japan	135	106/29	69	NLR	3.0	-	-	RNU	0	30	RFS	36.1	7
Son et al. 2018 [28]	2004–2015	Korea	1137	825/312	69	NLR, PLR	3.3	142	-	RNU	NA	348	CSS, RFS	39.1 (18.3–63.8)	7
Tan et al. 2018 [29]	2004–2015	China	717	408/309	67	NLR	2.5	-	-	RNU	0	291	OS, CSS, RFS	42 (1–167)	7
Zhang et al. 2018 [30]	1990–2011	China	100	79/21	Mean = 68.3	MLR	-	-	3.0	RNU	0	NA	OS	Mean = 45.83 (1–151)	7
Altan et al. 2017 [16]	1990–2017	Turkey	113	86/27	Mean = 63.7	NLR, PLR, MLR	2.9	150	2.9	RNU	NA	0	DFS, PFS	34 (3–186)	6
Dalpiaz et al. 2017 [17]	1990–2012	Austria	180	109/71	70	PLR	-	150	-	RNU	NA	NA	OS, CSS	30	7
Huang et al. 2017 [31]	2003–2013	China	425	279/146	Mean = 65.9	NLR	2.955	-	-	RNU	0	86	OS, CSS	38.5 (23–62)	7
Jiang et al. 2017 [32]	2005-2015	China	113	76/37	Mean = 64.86	PLR	-	150	-	RNU	NA	32	CSS, RFS	29 (2–113)	6
Kang et al. 2017 [18]	1994–2012	Korea	90	67/23	62	NLR	2.9	-	-	RNU	0	90	OS, CSS	NA	6
Vartolomei et al. 2017 [19]	1990–2008	Austria	2274	1527/747	69	NLR	2.7	-	-	RNU	0	217	CSS, RFS	40 (20–76)	8
Cheng et al. 2016 [20]	2005–2010	Taiwan	195	79/116	Mean = 68	NLR	2.7	-	-	RNU	NA	35	OS, CSS	36	7
Huang et al. 2016 [33]	2002–2013	China	481	311/170	Mean = 65.8	NLR, PLR	3.22	241.2	-	RNU	0	96	OS, CSS	40 (24–64)	7
Song et al. 2016 [34]	2005–2011	China	140	86/54	67	NLR, PLR, MLR	2.2	128	3.6	RNU	NA	0	DFS, PFS	45 (11–108)	7
Hutterer et al. 2015 [35]	1990–2012	Austria	182	111/71	Mean = 69.0	MLR	-	-	2.0	RNU	NA	NA	OS	NA	7
Tanaka et al. 2015 [36]	1995–2011	Japan	394	289/105	70	NLR	3.0	-	-	RNU	0	88	CSS, RFS	30 (15–63)	7
Dalpiaz et al. 2014 [37]	1990–2012	Austria	202	122/80	Mean = 69.3	NLR	2.7	-	-	RNU	0	0	OS, CSS	45 (0–199)	8
Luo et al. 2014 [38]	2005–2010	Taiwan	234	102/132	NA	NLR	3.0	-	-	RNU	0	0	CSS, MFS	Mean = 40.7	7
Tanaka et al. 2014 [39]	1993–2011	Japan	665	493/172	Mean = 70	NLR	3.0	-	-	RNU	0	129	CSS, RFS	28 (14–57)	7
Azuma et al. 2013 [40]	1994–2008	Japan	137	106/31	Mean = 69.4	NLR	2.5	-	-	RNU	NA	NA	CSS, RFS	60.9 (6.9–187.3)	7

AC Adjuvant chemotherapy, NA Not available, NAC Neoadjuvant chemotherapy, NOS score Newcastle-Ottawa Scale score, RNU Radical nephroureterectomy

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