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Table 1 Characteristics of the studies included in the meta-analysis

From: Prognostic value of preoperative lymphocyte-related systemic inflammatory biomarkers in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: a systematic review and meta-analysis

Author and year Period Region Sample size Gender (M/F) Median age Type of biomarker Cutoff value Surgery NAC AC Outcome Follow-up (months) NOS score
NLR PLR MLR
Xu et al. 2020 [24] 2003–2016 China 703 399/304 67 NLR 2.5 - - RNU 0 287 OS, CSS, RFS 42 (1–168) 7
Jan et al. 2019 [13] 2007–2017 Taiwan 424 189/235 70 NLR, PLR, MLR 4.0 150 0.4 RNU 0 40 OS, CSS, PFS 35 (14–60) 7
Kuroda et al. 2019 [14] 1999–2017 Japan 187 138/49 71 NLR, PLR 2.035 165 - RNU 4 53 CSS, RFS Mean = 49.2 (3.4-209.2) 7
Li et al. 2019 [25] 2008–2017 China 704 401/303 Mean = 66 MLR - - 3.6 RNU 0 286 OS, CSS, RFS 36 (34–43) 7
Zheng et al. 2019 [15] 2005–2015 China 259 185/74 Mean = 67.5 NLR, PLR, MLR 2.53 126.88 0.35 RNU 0 28 OS, CSS, MFS 33.3 (15.5–64.2) 8
Kohada et al. 2018 [26] 1999–2016 Japan 148 112/36 Mean = 71 NLR 3.0 - - RNU 0 25 CSS, RFS 35.5 7
Nishikawa et al. 2018 [27] 2005–2015 Japan 135 106/29 69 NLR 3.0 - - RNU 0 30 RFS 36.1 7
Son et al. 2018 [28] 2004–2015 Korea 1137 825/312 69 NLR, PLR 3.3 142 - RNU NA 348 CSS, RFS 39.1 (18.3–63.8) 7
Tan et al. 2018 [29] 2004–2015 China 717 408/309 67 NLR 2.5 - - RNU 0 291 OS, CSS, RFS 42 (1–167) 7
Zhang et al. 2018 [30] 1990–2011 China 100 79/21 Mean = 68.3 MLR - - 3.0 RNU 0 NA OS Mean = 45.83 (1–151) 7
Altan et al. 2017 [16] 1990–2017 Turkey 113 86/27 Mean = 63.7 NLR, PLR, MLR 2.9 150 2.9 RNU NA 0 DFS, PFS 34 (3–186) 6
Dalpiaz et al. 2017 [17] 1990–2012 Austria 180 109/71 70 PLR - 150 - RNU NA NA OS, CSS 30 7
Huang et al. 2017 [31] 2003–2013 China 425 279/146 Mean = 65.9 NLR 2.955 - - RNU 0 86 OS, CSS 38.5 (23–62) 7
Jiang et al. 2017 [32] 2005-2015 China 113 76/37 Mean = 64.86 PLR - 150 - RNU NA 32 CSS, RFS 29 (2–113) 6
Kang et al. 2017 [18] 1994–2012 Korea 90 67/23 62 NLR 2.9 - - RNU 0 90 OS, CSS NA 6
Vartolomei et al. 2017 [19] 1990–2008 Austria 2274 1527/747 69 NLR 2.7 - - RNU 0 217 CSS, RFS 40 (20–76) 8
Cheng et al. 2016 [20] 2005–2010 Taiwan 195 79/116 Mean = 68 NLR 2.7 - - RNU NA 35 OS, CSS 36 7
Huang et al. 2016 [33] 2002–2013 China 481 311/170 Mean = 65.8 NLR, PLR 3.22 241.2 - RNU 0 96 OS, CSS 40 (24–64) 7
Song et al. 2016 [34] 2005–2011 China 140 86/54 67 NLR, PLR, MLR 2.2 128 3.6 RNU NA 0 DFS, PFS 45 (11–108) 7
Hutterer et al. 2015 [35] 1990–2012 Austria 182 111/71 Mean = 69.0 MLR - - 2.0 RNU NA NA OS NA 7
Tanaka et al. 2015 [36] 1995–2011 Japan 394 289/105 70 NLR 3.0 - - RNU 0 88 CSS, RFS 30 (15–63) 7
Dalpiaz et al. 2014 [37] 1990–2012 Austria 202 122/80 Mean = 69.3 NLR 2.7 - - RNU 0 0 OS, CSS 45 (0–199) 8
Luo et al. 2014 [38] 2005–2010 Taiwan 234 102/132 NA NLR 3.0 - - RNU 0 0 CSS, MFS Mean = 40.7 7
Tanaka et al. 2014 [39] 1993–2011 Japan 665 493/172 Mean = 70 NLR 3.0 - - RNU 0 129 CSS, RFS 28 (14–57) 7
Azuma et al. 2013 [40] 1994–2008 Japan 137 106/31 Mean = 69.4 NLR 2.5 - - RNU NA NA CSS, RFS 60.9 (6.9–187.3) 7
  1. AC Adjuvant chemotherapy, NA Not available, NAC Neoadjuvant chemotherapy, NOS score Newcastle-Ottawa Scale score, RNU Radical nephroureterectomy