NCI-CTC grade (ver.5) | CBDCA + GEM (n = 65) | CDDP + VNR (n = 17) | Â | ||||
---|---|---|---|---|---|---|---|
G1/2 (%) | G3/4 (%) | total | G1/G2 (%) | G3/4 (%) | total | P | |
Hematological event | |||||||
 White blood cell decreased | 21 (32.3) | 0 | 21 (32.3) | 6 (35.2) | 0 | 6 (35.2) | 0.925 |
 Neutropenia | 18 (27.6) | 10 (15.3) | 28 (43.0) | 3 (17.6) | 8(47.0) | 11 (64.7) | 0.002* |
 Thrombocytopenia | 21 (32.2) | 3 (4.6) | 24 (36.9) | 2 (11.7) | 0 | 2 (11.7) | 0.377 |
 Anemia | 5 (7.6) | 0 | 5 (7.6) | 1 (5.8) | 0 | 1 (5.8) | 0.076 |
 Febrile neutropenia | 0 | 0 | 0 | 0 | 0 | 0 |  |
Non-hematological event | |||||||
 Nausea | 5 (7.6) | 0 | 5 (7.6) | 10 (58.8) | 2(11.7) | 1 2(70.5) | < 0.001* |
 Anorexia | 5 (7.6) | 0 | 5 (7.6) | 6 (35.2) | 3(17.6) | 9 (52.9) | < 0.001* |
 Mucositis oral | 2 (3.0) | 0 | 2 (3.0) | 0 | 0 | 0 | 0.464 |
 Fatigue | 7 (10.7) | 0 | 7 (10.7) | 7 (41.1) | 0 | 7 (41.1) | 0.045* |
 AST increased | 5 (7.6) | 0 | 5 (7.6) | 1 (5.8) | 0 | 1 (5.8) | 0.798 |
 ALT increased | 10 (15.3) | 0 | 10 (15.3) | 3 (17.6) | 0 | 3 (17.6) | 0.272 |
 Creatinine increased | 2 (3.0) | 0 | 2 (3.0) | 2 (11.7) | 0 | 2 (11.7) | 0.121 |
 Constipation | 14 (21.5) | 0 | 14 (21.5) | 2 (11.7) | 0 | 2 (11.7) | 0.631 |
 Diarrhea | 1 (1.5) | 0 | 1 (1.5) | 0 | 0 | 0 | 0.606 |
 Pneumonitis | 1 (1.5) | 0 | 1 (1.5) | 0 | 1(5.8) | 1 (5.8) | 0.128 |
 Infection | 1 (1.5) | 0 | 1 (1.5) | 0 | 0 | 0 | 0.606 |
 Rash | 3 (4.6) | 0 | 3 (4.6) | 0 | 0 | 0 | 0.665 |
 Hypophosphatemia | 1 (1.5) | 0 | 1 (1.5) | 0 | 0 | 0 | 0.606 |
 Vertigo | 2 (3.0) | 0 | 2 (3.0) | 1 (5.8) | 0 | 1 (5.8) | 0.583 |
 Insomnia | 1 (1.5) | 0 | 1 (1.5) | 0 | 0 | 0 | 0.606 |
 Alopecia | 1 (1.5) | 0 | 1 (1.5) | 0 | 0 | 0 | 0.606 |
 Peripheral nerve disorder | 1 (1.5) | 0 | 1 (1.5) | 0 | 0 | 0 | 0.606 |
 Supraventricular tachycardia | 0 | 1 (1.5) | 1 (1.5) | 0 | 0 | 0 | 0.606 |
 Vasculitis | 0 | 0 | 0 | 5 (29.4) | 0 | 5 (29.4) | < 0.001* |