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Fig. 6 | World Journal of Surgical Oncology

Fig. 6

From: Hsa_circ_0000231 knockdown inhibits the glycolysis and progression of colorectal cancer cells by regulating miR-502-5p/MYO6 axis

Fig. 6

MiR-502-5p regulates the biologic behavior of CRC by binding to MYO6. a MYO6 attenuated the inhibition effect of miR-502-5p on MYO6 protein expression in HCT116 and LoVo cells. b and c MYO6 overexpression hindered the inhibition effects of miR-502-5p on cell viability and colony-forming ability in HCT116 and LoVo cells. d MYO6 restored the promotion effect of miR-502-5p on cell apoptosis in HCT116 and LoVo cells. e MYO6 restored the promotion effect of miR-502-5p mimic on C-caspase-3 activity in HCT116 and LoVo cells. f and g Enforced MYO6 expression hindered the inhibition effects of miR-502-5p mimic on glucose uptake and lactate production in HCT116 and LoVo cells. h MYO6 overexpression hindered the inhibition effect of miR-502-5p on HK2 protein expression in HCT116 and LoVo cells. *P < 0.05

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