Fig. 4

Hsa_circ_0000231 regulates the proliferation, glycolysis, and apoptosis of CRC cells by sponging miR-515-5p. a MiR-502-5p inhibitor restrained the promotion effects of hsa_circ_0000231 knockdown on miR-502-5p expression in HCT116 and LoVo cells. b-d MiR-502-5p inhibitor restrained the repression effect of hsa_circ_0000231 knockdown on the proliferation of HCT116 and LoVo cells. e MiR-502-5p inhibitor hindered the promotion impact of hsa_circ_0000231 knockdown on the apoptosis of HCT116 and LoVo cells. f MiR-502-5p inhibitor restrained the promotion effect of hsa_circ_0000231 silencing on C-caspase-3 activity in both HCT116 and LoVo cells. g and h MiR-502-5p inhibitor abolished the repression effectS of hsa_circ_0000231 knockdown on glucose uptake and lactate production in both HCT116 and LoVo cells. i MiR-502-5p inhibitor restrained the repression effect of hsa_circ_0000231 knockdown on HK2 protein expression in both HCT116 and LoVo cells. *P < 0.05