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Table 4 Prognostic factors of disease-free survival

From: HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis

Factors 3-year survival (%) Univariate Multivariate
HR (95% CI) p value HR (95% CI) p value
Primary factors
 Location Colon/rectum 27.3/30.7 1.17 (0.67–2.10) 0.4980   
 Depth < SS/> SS 18.8/31.2 0.77 (0.23–1.91) 0.6370   
 Diff. Diff/undiff 31.1/0 3.16 (1.00–8.92) 0.0466 2.14 (0.50–6.27) 0.2650
 Lymphatic invasion −/+ 32.6/31.0 1.05 (0.58–1.87) 0.7784   
 Vessel invasion −/+ 28.0/32.7 0.92 (0.50–1.64) 0.9157   
 LN metastasis −/+ 50.7/18.4 1.91 (1.07–3.51) 0.0146 2.03 (1.12–3.79) 0.0186
 HIF-1α −/+ 33.3/31.2 1.03 (0.56–1.83) 0.9122   
Metastatic factors
 Meta. period Meta/syn 39.6/23.8 1.71 (0.97–3.13) 0.0693   
 Tumor size (cm) < 5/> 5 26.1/41.7 0.95 (0.52–1.86) 0.8708   
 Tumor number < 5/> 5 30.8/27.8 1.58 (0.79–2.94) 0.1647   
 H class H1/H2.3 31.3/27.9 1.55 (0.88–2.70) 0.1224   
 Grade A/B.C 37.6/22.7 2.02 (1.16–3.58) 0.0119 2.21 (1.26–3.94) 0.0057
 Adjuvant therapy −/+ 30.2/23.8 1.54 (0.96–3.34) 0.1681   
 Hepatectomy Minor/major 28.8/46.2 0.97 (0.44–1.92) 0.9361   
 HIF-1α −/+ 52.2/19.6 2.48 (1.30–5.16) 0.0073 2.40 (1.25–5.01) 0.0079
 CA19-9 < 100/> 100 63.5/37.5 1.71 (0.74–4.98) 0.5631   
 CEA < 10/> 10 27.6/30.1 1.19 (0.66–2.20) 0.5739   
  1. Diff differentiated type, undiff undifferentiated type, LN lymph node, SS subserous, Meta metachronous, Syn synchronous, HR hazard ratio, CI confidence interval