Table 4 Prognostic factors of disease-free survival

 Location

Colon/rectum

27.3/30.7

1.17 (0.67–2.10)

0.4980

 Depth

< SS/> SS

18.8/31.2

0.77 (0.23–1.91)

0.6370

 Diff.

Diff/undiff

31.1/0

3.16 (1.00–8.92)

0.0466

2.14 (0.50–6.27)

0.2650

 Lymphatic invasion

−/+

32.6/31.0

1.05 (0.58–1.87)

0.7784

 Vessel invasion

−/+

28.0/32.7

0.92 (0.50–1.64)

0.9157

 LN metastasis

−/+

50.7/18.4

1.91 (1.07–3.51)

0.0146

2.03 (1.12–3.79)

0.0186

 HIF-1α

−/+

33.3/31.2

1.03 (0.56–1.83)

0.9122

 Meta. period

Meta/syn

39.6/23.8

1.71 (0.97–3.13)

0.0693

 Tumor size (cm)

< 5/> 5

26.1/41.7

0.95 (0.52–1.86)

0.8708

 Tumor number

< 5/> 5

30.8/27.8

1.58 (0.79–2.94)

0.1647

 H class

H1/H2.3

31.3/27.9

1.55 (0.88–2.70)

0.1224

 Grade

A/B.C

37.6/22.7

2.02 (1.16–3.58)

0.0119

2.21 (1.26–3.94)

0.0057

 Adjuvant therapy

−/+

30.2/23.8

1.54 (0.96–3.34)

0.1681

 Hepatectomy

Minor/major

28.8/46.2

0.97 (0.44–1.92)

0.9361

 HIF-1α

−/+

52.2/19.6

2.48 (1.30–5.16)

0.0073

2.40 (1.25–5.01)

0.0079

 CA19-9

< 100/> 100

63.5/37.5

1.71 (0.74–4.98)

0.5631

 CEA

< 10/> 10

27.6/30.1

1.19 (0.66–2.20)

0.5739