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Table 3 Prognostic factors of overall survival

From: HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis

Factors 5-year survival (%) Univariate Multivariate
HR (95% CI) p value HR (95% CI) p value
Primary factors
 Location Colon/rectum 56.0/58.0 1.03 (0.46–2.24) 0.9357   
 Depth < SS/> SS 65.6/58.9 0.93 (0.28–5.81) 0.9242   
 Diff. Diff/undiff 59.1/0 23.90 (4.58–112.20) < 0.0001 20.87 (3.78–107.13) 0.0013
 Lymphatic invasion −/+ 66.5/53.7 0.93 (0.43–2.13) 0.9569   
 Vessel invasion −/+ 59.9/56.7 1.16 (0.53–2.75) 0.7172   
 LN metastasis −/+ 70.3/48.7 1.53 (0.70–3.59) 0.3019   
 HIF-1α −/+ 60.4/54.6 1.21 (0.55–2.85) 0.6424   
Metastatic factors
 Meta. period Meta/syn 69.0/49.8 1.79 (0.79–4.59) 0.1826   
 Tumor size (cm) < 5/> 5 60.5/47.2 1.85 (0.81–4.04) 0.1213   
 Tumor number < 5/> 5 58.4/51.1 1.67 (0.68–3.72) 0.2231   
 H class H1/H2.3 63.8/46.0 2.22 (1.02–4.96) 0.0400 1.19 (0.41–4.31) 0.7591
 Grade A/B.C 72.7/44.2 2.89 (1.27–7.42) 0.0119 2.37 (0.20-0.61) 0.1996
 Adjuvant therapy −/+ 68.3/54.4 1.22 (0.53–3.13) 0.6514   
 Hepatectomy Minor/major 52.6/64.7 0.68 (0.20–1.79) 0.4832   
 HIF-1α −/+ 75.8/54.9 3.26 (1.24–11.17) 0.0220 2.85 (1.04–10.01) 0.0422
 CA19-9 < 100/> 100 28.2/37.5 0.73 (0.27–2.53) 0.2557   
 CEA < 10/> 10 57.4/55.1 1.45 (0.60–3.84) 0.4164   
  1. Diff differentiated type, undiff undifferentiated type, LN lymph node, SS subserous, Meta metachronous, Syn synchronous, HR hazard ratio, CI confidence interval