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Table 2 Clinicopathological factors according to HIF-1α expression in primary site

From: HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis

Factors   Low expression (n = 24) High expression (n = 51) p value
Primary factors
 Location Colon/rectum 16/8 30/21 0.5130
 Depth < SS/≥ SS 1/23 6/45 0.2601
 Diff. Diff/undiff 23/1 48/3 0.7528
 Lymphatic invasion −/+ 10/14 19/31 0.6476
 Vessel invasion −/+ 6/18 16/35 0.5684
 LN metastasis −/+ 9/15 23/28 0.5334
Metastatic factors
 Meta. period Meta/syn 7/17 25/26 0.1005
 Tumor size (cm) < 5≥ 5 18/6 39/12 0.8896
 Tumor number < 5/≥ 5 19/5 41/10 0.9018
 H class H1/H2.3 14/10 32/19 0.7150
 Grade A/B.C 11/13 27/24 0.5656
 Adjuvant therapy −/+ 8/16 22/29 0.4188
 Hepatectomy Minor/major 17/7 45/6 0.1633
 CA19-9a < 100/≥ 100 19/1 40/7 0.2196
 CEAa < 10/≥ 10 10/10 29/18 0.3758
  1. Diff differentiated type, undiff undifferentiated type, LN lymph node, SS subserous, Meta metachronous, Syn synchronous
  2. a8 patients are not available