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Table 1 Clinicopathological factors according to HIF-1α expression in metastatic site

From: HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis

Factors   Low expression (n = 21) High expression (n = 54) p value
Primary factors
 Location Colon/rectum 12/9 34/20 0.6433
 Depth < SS/≥ SS 2/19 5/49 0.9718
 Diff. Diff/undiff 20/1 51/3 0.8896
 Lymphatic invasion −/+ 9/12 20/33 0.6614
 Vessel invasion −/+ 5/16 17/37 0.5068
 LN metastasis −/+ 8/13 24/30 0.6165
Metastatic factors
 Meta. period Meta/syn 10/11 22/32 0.5895
 Tumor size (cm) < 5/≥ 5 15/6 42/12 0.5678
 Tumor number < 5/≥ 5 17/4 43/11 0.8973
 H class H1/H2.3 12/9 34/20 0.6433
 Grade A/B.C 12/9 26/28 0.4836
 Adjuvant therapy −/+ 8/13 22/32 0.8337
 Hepatectomy Minor/major 16/5 46/8 0.3555
 CA19-9a < 100/≥ 100 16/4 43/4 0.2014
 CEAa < 10/≥ 10 12/8 27/20 0.8461
  1. Diff differentiated type, undiff undifferentiated type, LN lymph node, SS subserous, Meta metachronous, Syn synchronous
  2. a8 patients are not available