Table 1 Clinicopathological factors according to HIF-1α expression in metastatic site

 Location

Colon/rectum

12/9

34/20

0.6433

 Depth

< SS/≥ SS

2/19

5/49

0.9718

 Diff.

Diff/undiff

20/1

51/3

0.8896

 Lymphatic invasion

−/+

9/12

20/33

0.6614

 Vessel invasion

−/+

5/16

17/37

0.5068

 LN metastasis

−/+

8/13

24/30

0.6165

 Meta. period

Meta/syn

10/11

22/32

0.5895

 Tumor size (cm)

< 5/≥ 5

15/6

42/12

0.5678

 Tumor number

< 5/≥ 5

17/4

43/11

0.8973

 H class

H1/H2.3

12/9

34/20

0.6433

 Grade

A/B.C

12/9

26/28

0.4836

 Adjuvant therapy

−/+

8/13

22/32

0.8337

 Hepatectomy

Minor/major

16/5

46/8

0.3555

 CA19-9^a

< 100/≥ 100

16/4

43/4

0.2014

 CEA^a

< 10/≥ 10

12/8

27/20

0.8461