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Table 1 Study characteristics of the 6 eligible articles

From: Potential prognostic value of delta-like protein 3 in small cell lung cancer: a meta-analysis

Study

Year

Country

No. of samples

Sex (male/female)

Smoking history (non/yes)

Distant metastasis (negative/positive)

Tumour stage (I-II/III-IV)

Histologic subtype

Method

Outcomes

Biomarkers

Cut-off value

Yan et al. [20]

2019

China

335

306/29

93/242

165/170

29/306

SCLC

IHC

OS

DLL3/TTF1

score ≥ 150

Xie et al. [21]

2019

USA

44

19/25

N/A

N/A

19/16

SCLC

IHC

OS

DLL3

≥ 50%

Tanaka et al. [22]

2018

Japan

63

52/11

3/60

N/A

N/A

SCLC

IHC

OS

DLL3

≥ 50%

Regzedmaa et al. [23]

2019

China

38

26/12

12/26

15/23

16/22

SCLC

IHC

OS

DLL3/CTLA-4/MSTN

score ≥ 13.5

Huang et al. [24]

2019

China

72

N/A

N/A

N/A

N/A

SCLC

IHC

OS/PFS

DLL3

score ≥ 6

Furuta et al. [25]

2019

Japan

93

72/21

18/75

N/A

82/11

SCLC

IHC

OS

DLL3/ASCL1

≥ 75%

  1. SCLC small cell lung cancer, IHC immunohistochemistry, OS overall survival, PFS progression-free survival, DLL3 delta-like protein 3, CTLA-4 cytotoxic T lymphocyte-associated protein 4, MSTN mesothelin, ASCL1 achaete-scute homologue-1, N/A not applicable