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Table 1 Characteristics of the included articles

From: Efficacy and safety of wait and see strategy versus radical surgery and local excision for rectal cancer with cCR response after neoadjuvant chemoradiotherapy: a meta-analysis

Study Year Country Case Age Quality control Diagnostic criteria Study design Neoadjuvant therapy Evaluation Follow-up time (month) Radical surgery type NOS score
WS RS LE WS RS LE Selection Comparability Outcome Time (week) WS RS LE APR or LAR
Ayloor [16] 2013 India 23 10 50 55 3 2 1 + CT, ultrasound RNCT Long-range radiotherapy 4–6 72 72 APR or LAR 6
Dalton [17] 2012 UK 6 6 68 69 3 2 2 PNCT Cape/45–50.4Gy 6–8 25.3 39.3 TME 7
Habr [11] 2004 Brazil 71 22 58.1 53.6 2 3 1 +CT PNCT 5-FU+LV/45–50.4Gy 6–8 57.3 48 TME 6
Lai [18] 2016 Taiwan 18 26 67.5 63.7 2 2 2 RNCT 5-FU/45–50.4Gy 8–12 49 42 APR or LAR or
LAR+ loop stoma
6
Lee [19] 2015 Korea 8 28 16 64 70 70 3 2 1 PNCT 50.4Gy 6–10 41 41 41 TME 6
Li [20] 2015 China 30 92 62 56 3 1 2 PNCT Cape/50;25Gy 8–10 58 58 APR or LAR 6
Mass [21] 2011 Netherlands 21 20 65 66 3 2 2 PNCT Cape/45Gy 6–8 25 35 TME 7
Renehan [22] 2016 UK 129 109 66.9 65 2 3 2 PNCT 5-FU/45Gy 8 33 33 TME 7
Smith [23] 2012 USA 32 57 70 60 3 3 1 PNCT 5-FU+ Cape/50.4Gy 4–10 28 43 7
Yeom [24] 2019 Korea 15 129 25 74 64.8 73 2 3 2 RNCT Cape /50.4Gy or Capeox/50.4Gy or 5-FU /50.4Gy 8 60 60 60 TME 7
Wang [25] 2020 China 59 179 58 57 2 2 2 RNCT 5-FU+ Cape/50.4Gy 6–12 60 60 TME 6
  1. Notes: PNCT prospective non-randomized controlled trial, RNCT retrospective non-randomized controlled trial, 5-FU 5-fluorouracil, Cape capecitabine, RS radical surgery, TME total mesorectal excision, APR abdomi-l-perineal resection, LAR low anterior resection
  2. Diagnostic criteria of cCR: no residual tumor and white scar in endoscopy, negative biopsies from the white scar, no palpable tumor with digital rectal exam (DRE), no suspicious lymph nodes in MRI, and no residual tumor or residual fibrosis in MRI