Table 1 The GO function enrichment analysis of four most significant MCODE components
From: Integrated analysis of RNA-binding proteins in human colorectal cancer
Ontology | ID | Description | Count | p value | p.adjust |
|---|---|---|---|---|---|
Sub-network 1 | |||||
 BP | GO:0042254 | Ribosome biogenesis | 46 | 1.57E−74 | 5.06E−72 |
 BP | GO:0016072 | rRNA metabolic process | 43 | 7.30E−73 | 1.18E−70 |
 BP | GO:0006364 | rRNA processing | 42 | 2.21E−71 | 2.38E−69 |
 CC | GO:0030684 | Preribosome | 27 | 5.03E−51 | 1.71E−49 |
 CC | GO:0034455 | t-UTP complex | 18 | 2.51E−33 | 4.26E−32 |
 CC | GO:0032040 | Small-subunit processome | 15 | 5.16E−29 | 5.84E−28 |
 MF | GO:0140098 | Catalytic activity, acting on RNA | 20 | 8.42E−19 | 6.90E−17 |
 MF | GO:0003724 | RNA helicase activity | 12 | 2.62E−17 | 1.08E−15 |
 MF | GO:0030515 | snoRNA binding | 8 | 1.60E−14 | 4.38E−13 |
Sub-network 2 | |||||
 BP | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 21 | 7.37E−26 | 1.03E−23 |
 BP | GO:0000398 | mRNA splicing, via spliceosome | 21 | 7.37E−26 | 1.03E−23 |
 BP | GO:0000375 | RNA splicing, via transesterification reactions | 21 | 8.71E−26 | 1.03E−23 |
 CC | GO:0071013 | Catalytic step 2 spliceosome | 13 | 6.97E−22 | 6.62E−20 |
 CC | GO:0000974 | Prp19 complex | 13 | 2.03E−21 | 9.66E−20 |
 CC | GO:0005682 | U5 snRNP | 13 | 3.10E−19 | 9.83E−18 |
 MF | GO:0090079 | Translation regulator activity, nucleic acid binding | 10 | 2.82E−14 | 2.23E−12 |
 MF | GO:0003743 | Translation initiation factor activity | 8 | 1.54E−13 | 4.37E−12 |
 MF | GO:0008135 | Translation factor activity, RNA binding | 9 | 1.66E−13 | 4.37E−12 |
Sub-network 3 | |||||
 BP | GO:0000460 | Maturation of 5.8S rRNA | 6 | 5.04E−18 | 5.24E−16 |
 BP | GO:0034427 | Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3′-5′ | 4 | 6.22E−13 | 3.23E−11 |
 BP | GO:0043629 | ncRNA polyadenylation | 4 | 1.47E−12 | 3.67E−11 |
 CC | GO:1905354 | Exoribonuclease complex | 6 | 2.17E−18 | 3.69E−17 |
 CC | GO:0000176 | Nuclear exosome (RNase complex) | 5 | 1.50E−15 | 1.27E−14 |
 CC | GO:0000178 | Exosome (RNase complex) | 5 | 1.03E−14 | 5.82E−14 |
 MF | GO:0017091 | AU-rich element binding | 3 | 7.07E−08 | 8.18E−07 |
 MF | GO:0000175 | 3′-5′-Exoribonuclease activity | 3 | 1.29E−07 | 8.18E−07 |
 MF | GO:0016896 | Exoribonuclease activity, producing 5′-phosphomonoesters | 3 | 1.54E−07 | 8.18E−07 |
Sub-network 4 | |||||
 BP | GO:0051028 | mRNA transport | 6 | 2.64E−13 | 1.90E−11 |
 BP | GO:0050657 | Nucleic acid transport | 6 | 1.13E−12 | 2.23E−11 |
 BP | GO:0050658 | RNA transport | 6 | 1.13E−12 | 2.23E−11 |
 CC | GO:0000346 | Transcription export complex | 3 | 5.69E−09 | 9.11E−08 |
 CC | GO:0016607 | Nuclear speck | 4 | 2.35E−06 | 1.88E−05 |
 CC | GO:0000784 | Nuclear chromosome, telomeric region | 2 | 0.000588204 | 0.003137089 |