Table 1 Comparison of clinicopathological features among Borrmann type I+II, III, and IV tumors
Variables | Borrmann I+II, N = 1096 (%) | Borrmann III, N = 850 (%) | p value | Borrmann IV, N = 146 (%) | p value |
|---|---|---|---|---|---|
Gender | Â | Â | 0.761 | Â | < 0.001 |
 Male | 789 (72.0) | 606 (71.3) |  | 83 (56.8) |  |
 Female | 307 (28.0) | 244 (28.7) |  | 63 (43.2) |  |
Age, years | Â | Â | 0.647 | Â | 0.216 |
 ≤ 60 | 590 (53.8) | 448 (52.7) |  | 87 (59.6) |  |
 > 60 | 506 (46.2) | 402 (47.3) |  | 59 (40.4) |  |
Tumor size, cm | Â | Â | < 0.001 | Â | < 0.001 |
 ≤ 5 | 715 (65.2) | 314 (36.9) |  | 17 (11.6) |  |
 > 5 | 381 (34.8) | 536 (63.1) |  | 129 (88.4) |  |
Tumor location | Â | Â | < 0.001 | Â | < 0.001 |
 Upper 1/3 | 359 (32.8) | 254 (29.9) |  | 38 (26.0) |  |
 Middle 1/3 | 113 (10.3) | 134 (15.8) |  | 34 (23.3) |  |
 Lower 1/3 | 619 (56.5) | 439 (51.6) |  | 27 (18.5) |  |
 Entire | 5 (0.5) | 23 (2.7) |  | 47 (32.2) |  |
Curative resection | Â | Â | < 0.001 | Â | < 0.001 |
 R0 | 1032 (94.2) | 726 (85.4) |  | 93 (63.7) |  |
 R1/2 | 64 (5.8) | 124 (14.6) |  | 53 (36.3) |  |
T stages | Â | Â | < 0.001 | Â | < 0.001 |
 T2 | 283 (25.8) | 76 (8.9) |  | 5 (3.4) |  |
 T3 | 289 (26.4) | 166 (19.5) |  | 10 (6.8) |  |
 T4a | 432 (39.4) | 480 (56.5) |  | 89 (61.0) |  |
 T4b | 82 (8.4) | 128 (15.1) |  | 42 (28.8) |  |
N stages | Â | Â | < 0.001 | Â | < 0.001 |
 N0 | 296 (27.0) | 123 (14.5) |  | 7 (4.8) |  |
 N1 | 207 (18.9) | 130 (15.3) |  | 12 (8.2) |  |
 N2 | 218 (19.9) | 190 (22.4) |  | 13 (8.9) |  |
 N3a | 256 (23.4) | 253 (29.8) |  | 38 (26.0) |  |
 N3b | 119 (10.9) | 154 (18.1) |  | 76 (52.1) |  |
M stage | Â | Â | < 0.001 | Â | < 0.001 |
 M0 | 1011 (92.2) | 732 (86.1) |  | 103 (70.5) |  |
 M1 | 85 (7.8) | 118 (13.9) |  | 43 (29.5) |  |
TNM stages | Â | Â | < 0.001 | Â | < 0.001 |
 I | 133 (12.1) | 21 (2.5) |  | 0 (0.0) |  |
 II | 329 (30.0) | 164 (19.3) |  | 9 (6.2) |  |
 III | 549 (50.1) | 547 (64.4) |  | 94 (64.4) |  |
 IV | 85 (7.8) | 118 (13.9) |  | 43 (29.4) |  |
Histologic type | Â | Â | 0.003 | Â | < 0.001 |
 G1/G2 | 397 (36.2) | 254 (29.9) |  | 20 (13.7) |  |
 G3/G4 | 699 (63.8) | 596 (70.1) |  | 126 (86.3) |  |
Lymphovascular invasion | Â | Â | 0.044 | Â | < 0.001 |
 Positive | 172 (15.7) | 163 (19.2) |  | 47 (32.2) |  |
 Negative | 924 (84.3) | 687 (80.8) |  | 99 (67.8) |  |
Perineural invasion | Â | Â | 0.001 | Â | 0.001 |
 Positive | 138 (12.6) | 151 (17.8) |  | 34 (23.3) |  |
 Negative | 958 (87.4) | 699 (82.2) |  | 112 (76.7) |  |
Combined organ resection | Â | Â | Â | Â | 0.556 |
 Yes | 55 (5.0) | 44 (5.2) | 0.917 | 9 (6.2) |  |
 No | 1041 (95.0) | 806 (94.8) |  | 137 (93.8) |  |
Postoperative chemotherapy | Â | Â | 0.466 | Â | 0.384 |
 Yes | 477 (43.5) | 384 (45.2) |  | 58 (39.7) |  |
 No | 619 (56.5) | 466 (54.8) |  | 88 (60.3) |  |