Table 3 Comparison of patient demographics and clinicopathological characteristics and their impact on OS between 2 time periods (2000 to 2010 vs 2011 to 2016)

0.712 (0.482–1.051)

0.0873

0.920 (0.504–1.680)

1.232 (0.866–1.752)

0.2462

1.173 (0.655–2.098)

1.411 (0.937–2.124)

0.0990

0.631 (0.282–1.414)

1.796 (1.050–3.070)

0.0324

3.383 (1.511–7.573)

2.417 (1.198–4.875)

0.0137

2.038 (0.639–6.504)

1.929 (0.899–4.139)

0.0918

0.907 (0.387–2.125)

1.663 (1.065–2.595)

0.0252

2.923 (1.543–5.538)

0.845 (0.571–1.250)

0.3998

0.899 (0.448–1.803)

1.313 (0.867–1.988)

0.1979

1.306 (0.612–2.788)

1.142 (0.763–1.710)

0.5185

1.608 (0.888–2.914)

1.074 (0.757–1.524)

0.6898

1.959 (1.117–3.435)

1.428 (1.010–2.019)

0.0441

1.627 (0.932–2.842)

1.400 (0.990–1.981)

0.0571

1.475 (0.853–2.552)

1.244 (0.798–1.940)

0.3344

1.473 (0.709–3.061)

0.300 (0.184–0.4904)

< 0.0001

0.472 (0.237–0.939)

1.478 (1.005–2.173)

0.0472

1.340 (0.770–2.331)

0.790 (0.553–1.128)

0.1945

1.126 (0.647–1.959)

1.478 (1.045–2.091)

0.0273

2.742 (1.538–4.888)